3-methyl-6-(2-nitroethyl)-2(3H)-benzoxazolone | 1201771-87-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑类
• 英文名称: 3-methyl-6-(2-nitroethyl)-2(3H)-benzoxazolone
• 英文别名: 3-Methyl-6-(2-nitroethyl)-1,3-benzoxazol-2-one；3-methyl-6-(2-nitroethyl)-1,3-benzoxazol-2-one
• CAS: 1201771-87-0
• 化学式: C₁₀H₁₀N₂O₄
• 分子量: 222.2
• InChiKey: OFKDVKJVKLYWIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  75.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-methyl-6-(2-nitroethyl)-2(3H)-benzoxazolone 在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 为溶剂， 反应 24.0h， 生成 3-methyl-6-(2-aminoethyl)-2(3H)-benzoxazolone
  参考文献：
  名称：

  Antioxidant activity of benzoxazolinonic and benzothiazolinonic derivatives in the LDL oxidation model

  摘要：

  A series of benzazolone compounds were synthesized utilizing benzoxazolinonic and benzothiazolinonic heterocycles as the building unit. The antioxidant activity of these compounds was determined by inhibition of lipid peroxidation. The oxidation of LDL was induced in the presence of CuSO4 or 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH). The protective action of these compounds against the cytotoxicity was evaluated with lactate dehydrogenase (LDH) activity in bovine aortic endothelial cells (BAECs) and cellular vitality by measuring mitochondrial activity in the presence of MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide). The best antioxidant activities were observed for phenolic compounds 13 and 14b with ratio R = 2.5, 3.2 (5 mu M). Both of these test substances increased the cell viability significantly as indicated by MTT assay and LDH release assay. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.09.016
• 作为产物：
  描述：

  3-methyl-6-(2-nitrovinyl)-2(3H)-benzoxazolone 在 sodium tetrahydroborate 、 silica gel 作用下， 以 氯仿 、 异丙醇 为溶剂， 反应 24.0h， 以68%的产率得到3-methyl-6-(2-nitroethyl)-2(3H)-benzoxazolone
  参考文献：
  名称：

  Antioxidant activity of benzoxazolinonic and benzothiazolinonic derivatives in the LDL oxidation model

  摘要：

  A series of benzazolone compounds were synthesized utilizing benzoxazolinonic and benzothiazolinonic heterocycles as the building unit. The antioxidant activity of these compounds was determined by inhibition of lipid peroxidation. The oxidation of LDL was induced in the presence of CuSO4 or 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH). The protective action of these compounds against the cytotoxicity was evaluated with lactate dehydrogenase (LDH) activity in bovine aortic endothelial cells (BAECs) and cellular vitality by measuring mitochondrial activity in the presence of MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide). The best antioxidant activities were observed for phenolic compounds 13 and 14b with ratio R = 2.5, 3.2 (5 mu M). Both of these test substances increased the cell viability significantly as indicated by MTT assay and LDH release assay. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.09.016

文献信息

• Antioxidant activity of benzoxazolinonic and benzothiazolinonic derivatives in the LDL oxidation model
  作者：Ismaël Yekini、Fatma Hammoudi、Françoise Martin-Nizard、Saïd Yous、Nicolas Lebegue、Pascal Berthelot、Pascal Carato

  DOI：10.1016/j.bmc.2009.09.016

  日期：2009.11

  A series of benzazolone compounds were synthesized utilizing benzoxazolinonic and benzothiazolinonic heterocycles as the building unit. The antioxidant activity of these compounds was determined by inhibition of lipid peroxidation. The oxidation of LDL was induced in the presence of CuSO4 or 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH). The protective action of these compounds against the cytotoxicity was evaluated with lactate dehydrogenase (LDH) activity in bovine aortic endothelial cells (BAECs) and cellular vitality by measuring mitochondrial activity in the presence of MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide). The best antioxidant activities were observed for phenolic compounds 13 and 14b with ratio R = 2.5, 3.2 (5 mu M). Both of these test substances increased the cell viability significantly as indicated by MTT assay and LDH release assay. (C) 2009 Elsevier Ltd. All rights reserved.