4-amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-6-hydrazino-pyrrolo[2,3-d]pyrimidine-5-carboxamide

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 吡咯并嘧啶核苷和核苷酸
• 英文名称: 4-amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-6-hydrazino-pyrrolo[2,3-d]pyrimidine-5-carboxamide
• 英文别名: 4-amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-hydrazinylpyrrolo[2,3-d]pyrimidine-5-carboxamide
• 化学式: C₁₂H₁₇N₇O₅
• 分子量: 339.31
• InChiKey: XCAQHWQRKUEFKS-OHOOMVFDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  208
• 氢给体数：
  7
• 氢受体数：
  10

文献信息

• NUCLEOSIDE COMPOUNDS AND METHODS OF USE THEREOF
  申请人：The Board of Trustees of the University of Illinois

  公开号：EP1876894A1

  公开（公告）日：2008-01-16
• COMPOUNDS FOR TREATING ABNORMAL CELLULAR PROLIFERATION
  申请人：Taiga Biotechnologies, Inc.

  公开号：EP2214670A2

  公开（公告）日：2010-08-11
• COMPOSITIONS AND METHODS OF TREATING MUSCULAR DYSTROPHY
  申请人：The Broad Institute, Inc.

  公开号：EP3207048A1

  公开（公告）日：2017-08-23
• Nucleoside compounds and methods of use thereof
  申请人：Gartel Andrei

  公开号：US20090117651A1

  公开（公告）日：2009-05-07

  The present invention provides methods of utilizing a nucleoside derivative having the chemical formula of Formula (I) to downregulate expression of an anti-apoptotic protein such as survivin in a cell, induce apoptosis in a cell, inhibit angiogenesis in a cell, inhibit binding of p53 to DNA in a cell, inhibit phosphorylation of Akt in a cell and inhibit HIV transcription in a cell, by administering to the cell or tissue an amount of a compound of Formula (I) sufficient to achieve the desired activity. Formula (I): wherein the substituents R a , R b , R c , R d , R e , R f , R g , R h , R i and R k are as defined in the specification. A particularly preferred nucleoside derivative is ARC (4-amino-6-hydrazino-7-beta-D-ribofuranosyl-7H-pyrrolo[2,3-d]-pyrimidine-5-carboxamide).
• METHOD FOR PREDICTING A SUBJECTS RESPONSE TO SLC MODULATOR THERAPY
  申请人：THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

  公开号：US20210254158A1

  公开（公告）日：2021-08-19

  The present invention provides, inter alia, methods for treating or ameliorating the effects of a disorder, such as schizophrenia or bipolar disorder, by increasing or decreasing proline levels. Further provided are methods of predicting and monitoring the clinical response in a patient, and diagnostic systems for identifying a patient likely to benefit from proline modulation.