(-) (-)-(2R,4R)-2-hydroxymethyl-4-(2'-amino-6'-cyclobutylamino-purine-9'-yl)-1,3-dioxolane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: (-) (-)-(2R,4R)-2-hydroxymethyl-4-(2'-amino-6'-cyclobutylamino-purine-9'-yl)-1,3-dioxolane
• 英文别名: [(2R,4R)-4-[2-amino-6-(cyclobutylamino)purin-9-yl]-1,3-dioxolan-2-yl]methanol
• 化学式: C₁₃H₁₈N₆O₃
• 分子量: 306.324
• InChiKey: ASODDDMBNNCHFM-RKDXNWHRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  120
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  (-)-(2R,4R)-2-benzoyloxymethyl-4-(2'-amino-6'-cyclobutylamino-purine-9'-yl)-1,3-dioxolane 以 methanolic ammonia 、 水 为溶剂， 以96%的产率得到(-) (-)-(2R,4R)-2-hydroxymethyl-4-(2'-amino-6'-cyclobutylamino-purine-9'-yl)-1,3-dioxolane
  参考文献：
  名称：

  Method for the treatment of Flaviviridea viral infection using nucleoside analogues

  摘要：

  根据本发明提供了一种治疗或预防宿主体内 Flaviviridea 病毒感染的方法，包括向宿主体内施用至少一种式（I）或（II）化合物或其药用盐的治疗有效量，其中Ra、R、Z和Y在申请中有定义。

  公开号：

  US06566365B1

文献信息

• Antiviral nucleoside analogues
  申请人：BioChem Pharma Inc.

  公开号：US20010049372A1

  公开（公告）日：2001-12-06

  In accordance with the present invention there is provided a nucleoside analogue of formula (I) or (Ia) which is useful as an antiviral agent.

  根据本发明提供了一种式(I)或(Ia)的核苷类似物，可作为抗病毒药物。
• Method for the treatment or prevention of Flaviviridea viral infection using nucleoside analogues
  申请人：BioChem Pharma Inc.

  公开号：US20030225037A1

  公开（公告）日：2003-12-04

  In accordance with the present invention there is provided a method for treating or preventing a Flaviviridea viral infection in a host comprising administering a therapeutically effective amount of at least one compound of formula (I) or (II) 1 or or a pharmaceutically acceptable salts thereof, wherein Ra, R, Z and Y are defined in the application.

  根据本发明，提供了一种用于治疗或预防宿主中的Flavivirideaviral感染的方法，包括给予至少一种式(I)或(II)1或它们的药学上可接受的盐的治疗有效量，其中Ra、R、Z和Y在申请中有定义。
• ANTIVIRAL NUCLEOSIDE ANALOGUES
  申请人：Shire BioChem Inc.

  公开号：EP1140937B1

  公开（公告）日：2003-11-12
• METHOD FOR THE TREATMENT OR PREVENTION OF i FLAVIVIRIDAE /i VIRAL INFECTION USING NUCLEOSIDE ANALOGUES
  申请人：BIOCHEM PHARMA INC

  公开号：EP1225899A2

  公开（公告）日：2002-07-31
• Topical composition for treatment of skin disorders
  申请人：Warren L. Stephen

  公开号：US20070142317A1

  公开（公告）日：2007-06-21

  The present invention provides for a topical composition that includes a topical carrier and an adenosine deaminase inhibitor. Suitable specific adenosine deaminase inhibitors include, e.g., deoxycoformycin (dCF), deoxyadenosine (dAdo), cladrabine (CdA), fludarabine (F-Ara-A), cytrabine (Ara-C), and thioguanine. The present invention also provides for a method to treat lymphocyte mediated skin diseases and to alleviate symptoms associated with such skin diseases. The method includes topically administering the composition to a mammal in need of such treatment. The present invention also provides for kits and syringe systems that include the adenosine deaminase inhibitor.