5-isoxazol-5-yl-2'-deoxyuridine

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 5-isoxazol-5-yl-2'-deoxyuridine
• 英文别名: 1-(4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-isoxazol-5-yl-1H-pyrimidine-2,4-dione；1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(1,2-oxazol-5-yl)pyrimidine-2,4-dione
• 化学式: C₁₂H₁₃N₃O₆
• 分子量: 295.252
• InChiKey: KPQSIUAPOSYYJU-FXBDTBDDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  125
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  5-(3-oxopropyn-1-yl)-2'-deoxyuridine 在 sodium hydrogensulfide 、 碳酸氢钠 、 hydroxylamine-O-sulfonic acid 作用下， 生成 5-isoxazol-5-yl-2'-deoxyuridine
  参考文献：
  名称：

  5-thien-2-yl-2'-deoxyuridine类似物的合成和抗病毒活性。

  摘要：

  使用四有机锡试剂和钯配合物作为催化剂，由5-碘-2'-脱氧尿苷合成了许多5-杂芳族取代的2'-脱氧尿苷。优化了5-碘-2'-脱氧尿苷与锡烷基化杂芳族化合物之间的钯催化的交叉偶联反应，以合成5-噻吩-3-基-2'-脱氧尿苷和5-呋喃-3-基-2' -脱氧尿苷。5-（5-碘噻吩-2-基）-2'-脱氧尿苷用作合成5-（5-甲基噻吩-2-基）-2'-脱氧尿苷，5-（5-乙烯基噻吩-2）的起始原料-基）-2'-脱氧尿苷和5-（5-乙炔基噻吩-2-基）-2'-脱氧尿苷。以硝酸铈铵为试剂合成了5-（5-硝基噻吩-2-基）-2'-脱氧尿苷。由5-（3-氧代丙炔-1-基）-2′-脱氧尿苷合成5-（异恶唑-5-基）-2′-脱氧尿苷。最后，通过将5-噻吩-2-基-β-卤化得到5-（5-氯噻吩-2-基）-β-D-阿拉伯呋喃糖基尿嘧啶和5-（5-溴噻吩-2-基）-β-D-阿拉伯呋喃糖基尿嘧啶。 D-阿拉伯呋喃糖基尿

  DOI：

  10.1021/jm00057a003

文献信息

• Compositions for increasing the survival of aquatic animals exposed to a RNA virus
  申请人：Sandino, Ana Maria

  公开号：EP1317923A2

  公开（公告）日：2003-06-11

  A method of increasing the survival of animals and aquatic species susceptible to birnavirus infection by treating them before, during and/or after birnavirus exposure, with a chemical compound capable of inhibiting viral RNA synthesis. A method of treating aquatic species to increase their survival in the presence of a virus, particularly an aquatic birnavirus, and to increase the yield of farmed fish susceptible to viral infection. The present invention provides methods for increasing survival of virally-exposed aquatic animals by administering therapeutically effective amounts of isoxazol compounds to aquatic animals susceptible to birnavirus infection and/or IPNV infection, particularly in fish such as salmonoid species, which are easily exposed to IPNV. The present invention also provides methods for increasing survival of virally-exposed animals by administering therapeutically effective amounts of isoxazol compounds to farmed animals susceptible to birnavirus infection and/or IBDV infection, particularly in poultry such as chickens, which are exposed to IBDV.

  一种方法，通过在动物和水生物种暴露于桦树病毒之前、期间和/或之后用一种能够抑制病毒 RNA 合成的化合物处理它们，提高易受桦树病毒感染的动物和水生物种的存活率。一种处理水生物种的方法，以提高其在病毒（尤其是水生鸟病毒）存在下的存活率，并增加易受病毒感染的养殖鱼类的产量。本发明提供了通过向易受桦树病毒感染和/或 IPNV 感染的水生动物，特别是易受 IPNV 感染的鱼类，如鲑科鱼类，施用治疗有效量的异噁唑化合物来提高受病毒感染的水生动物存活率的方法。本发明还提供了通过向易受桦树病毒感染和/或 IBDV 感染的养殖动物，特别是易受 IBDV 感染的家禽如鸡，施用治疗有效量的异恶唑化合物来提高病毒暴露动物存活率的方法。
• Methods for increasing the survival of aquatic and other animals exposed to an aquatic virus, birnavirus or other RNA virus and compositions for such methods
  申请人：——

  公开号：US20030191169A1

  公开（公告）日：2003-10-09

  A method of increasing the survival of animals and aquatic species susceptible to birnavirus infection by treating them before, during and/or after birnavirus exposure, with a chemical compound capable of inhibiting viral replication. A method of treating aquatic species to increase their survival in the presence of a virus, particularly an aquatic birnavirus, and to increase the yield of farmed fish susceptible to viral infection. The present invention provides methods for increasing survival of virally-exposed aquatic animals by administering therapeutically effective amounts of isoxazol compounds to aquatic animals susceptible to birnavirus infection and/or IPNV infection, particularly in fish such as salmonoid species, which are easily exposed to IPNV. The present invention also provides methods for increasing survival of virally-exposed animals by administering therapeutically effective amounts of isoxazol compounds to farmed animals susceptible to birnavirus infection and/or IBDV infection, particularly in poultry such as chickens, which are exposed to IBDV.

  一种方法，通过在动物和水生物种暴露于伯尔尼病毒之前、期间和/或之后用能够抑制病毒复制的化合物处理它们，提高易受伯尔尼病毒感染的动物和水生物种的存活率。一种处理水生物种的方法，以提高其在病毒（尤其是水生鸟病毒）存在下的存活率，并增加易受病毒感染的养殖鱼类的产量。本发明提供了通过向易受桦树病毒感染和/或 IPNV 感染的水生动物，特别是易受 IPNV 感染的鱼类，如鲑科鱼类，施用治疗有效量的异噁唑化合物来提高受病毒感染的水生动物存活率的方法。本发明还提供了通过向易受桦树病毒感染和/或 IBDV 感染的养殖动物，特别是易受 IBDV 感染的家禽如鸡，施用治疗有效量的异恶唑化合物来提高病毒暴露动物存活率的方法。
• PROCEDURE FOR OPERATING A PARTICLE FILTER ARRANGED IN AN EXHAUST FUME AREA OF A BRENNKRAFTMASCHINE AND DEVICE TO EXECUTE THE PROCEDURE
  申请人：Sandino Ana Maria

  公开号：US20100204290A1

  公开（公告）日：2010-08-12

  A method of increasing the survival of animals and aquatic species susceptible to birnavirus infection by treating them before, during and/or after bimavirus exposure, with a chemical compound capable of inhibiting viral replication. A method of treating aquatic species to increase their survival in the presence of a virus, particularly an aquatic bimavirus, and to increase the yield of farmed fish susceptible to viral infection. The present invention provides methods for increasing survival of virally-exposed aquatic animals by administering therapeutically effective amounts of isoxazol compounds to aquatic animals susceptible to bimavirus infection and/or IPNV infection, particularly in fish such as salmonoid species, which are easily exposed to IPNV. The present invention also provides methods for increasing survival of virally-exposed animals by administering therapeutically effective amounts of isoxazol compounds to farmed animals susceptible to bimavirus infection and/or IBDV infection, particularly in poultry such as chickens, which are exposed to IBDV.
• US7652050B2
  申请人：——

  公开号：US7652050B2

  公开（公告）日：2010-01-26
• US8044031B2
  申请人：——

  公开号：US8044031B2

  公开（公告）日：2011-10-25