(R)-2-(Tetrahydropyranyloxy)propionic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: (R)-2-(Tetrahydropyranyloxy)propionic acid
• 英文别名: 2-(oxan-2-yloxy)propanoic acid
• 化学式: C₈H₁₄O₄
• 分子量: 174.19
• InChiKey: CEFRORNCZFPJCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] BIARYL DERIVATIVES AS YAP/TAZ-TEAD PROTEIN-PROTEIN INTERACTION INHIBITORS<br/>[FR] DÉRIVÉS BIARYLE EN TANT QU'INHIBITEURS D'INTERACTION PROTÉINE-PROTÉINE YAP/TAZ-TEAD
  申请人：NOVARTIS AG

  公开号：WO2021186324A1

  公开（公告）日：2021-09-23

  The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; (I) a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.

  本发明提供了化合物(I)或其药学上可接受的盐；(I)制造所述化合物的方法及其治疗用途。本发明还提供了药理活性剂的组合物和包括所述化合物的药物组合。
• GRISEOFULVIN COMPOUND AND PHARMACEUTICAL USE THEREOF
  申请人：Daiichi Sankyo Company, Limited

  公开号：US20200216433A1

  公开（公告）日：2020-07-09

  The present invention addresses the problem of providing a compound for prophylaxis and/or treatment of central inflammatory diseases, or a pharmacologically acceptable salt thereof. The present invention addresses a compound of a general formula (I) or a pharmacologically acceptable salt thereof as a means to solve the problem. [R 1 : a C1-C6 alkyl group or the like, R 2 : a C1-C6 alkyl group or the like, A: a 5-membered aromatic hetero-ring or the like, R 3 , R 3′ : a C1-C6 alkyl group or the like]

  本发明旨在解决提供用于预防或治疗中枢性炎症性疾病的化合物或其药理上可接受的盐的问题。本发明提出了一种通式（I）的化合物或其药理上可接受的盐作为解决问题的手段。[R1：C1-C6烷基等，R2：C1-C6烷基等，A：5员芳香杂环等，R3，R3'：C1-C6烷基等]
• Optically active halohydrin derivative and process for producing optically active epoxy alcohol derivative from the same
  申请人：Okuro Kazumi

  公开号：US20060155136A1

  公开（公告）日：2006-07-13

  The present invention provides an industrially safe, easily operable process for producing an optically active epoxy alcohol derivative useful as an intermediate for pharmaceuticals from inexpensively available materials, and also provides a novel halohydrin derivative serving as an important intermediate for the epoxy alcohol derivative. Furthermore, the present invention provides a process for producing an intermediate for a triazole antifungal agent by allowing a halohydrin to react with a triazole sulfonamide, the process including a small number of steps. A process for producing an optically active epoxy alcohol derivative includes allowing an optically active α-substituted propionate derivative to react with a haloacetic acid derivative in the presence of a base to prepare an optically active haloketone derivative, allowing the resulting haloketone derivative to react with an aryl metal compound to stereoselectively prepare a halohydrin derivative, eliminating a substituent for the hydroxy group of the halohydrin derivative, and performing epoxidation with a base. Furthermore, a process for producing an intermediate for a triazole antifungal agent includes allowing a halohydrin derivative to react with a triazole sulfonamide, the process including a small number of steps.

  本发明提供了一种工业安全、易于操作的过程，用于从价格便宜的原料中生产有用于制药中间体的光学活性环氧醇衍生物，并提供了一种新型的卤代醇衍生物，作为环氧醇衍生物的重要中间体。此外，本发明提供了一种通过让卤代醇与三唑磺酰胺反应来生产三唑类抗真菌剂中间体的过程，包括少量的步骤。生产光学活性环氧醇衍生物的过程包括在碱的存在下让光学活性α-取代丙酸酯衍生物与卤代乙酸衍生物反应，以制备光学活性卤代酮衍生物，让产生的卤代酮衍生物与芳基金属化合物反应，选择性地立体定向制备卤代醇衍生物，消除卤代醇衍生物的羟基取代基，并在碱的存在下进行环氧化。此外，生产三唑类抗真菌剂中间体的过程包括让卤代醇衍生物与三唑磺酰胺反应，该过程包括少量的步骤。
• Nitrogen-containing heterocyclic compounds, and their production and use
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0128648A1

  公开（公告）日：1984-12-19

  A nitrogen-containing heterocyclic compound of the formula: wherein R, is either one of the following groups: (in which R7, R8, R9, R10, R11, R12, R13, R14, R15, R16 and R17 are each independently a hydrogen atom, a halogen atom, a C1-C4 alkyl group, a C1-C4 alkoxy group, a C1-C4 alkylthio group, a trifluoromethyl group or a nitro group, R18, R19, R20 and R21 are each independently a hydrogen atom or a methyl group, k is 0 or 1 and I is 0 or an integer of 1 to 3); R2 and R3 are each independently a hydrogen atom, a halogen atom or a methyl group; R4 is a halogen atom or a methyl group; Rs and R6 are each independently a hydrogen atom, a halogen atom, a C1-C4 alkyl group, a C1-C4 alkoxy group, a C1-C4 haloalkyl group or a C1-C4 haloalkoxy group; X, Y and Z are each independently an oxygen atom, a sulfur atom or a methylene group; m is 0 or an integer of 1 to 4; and n is 0 or an integer of 1 or 2, which is useful as an insecticidal agent.

  式中的含氮杂环化合物： 其中 R，是下列基团之一： (其中R7、R8、R9、R10、R11、R12、R13、R14、R15、R16和R17各自独立地为氢原子、卤素原子、C1-C4烷基、C1-C4烷氧基、C1-C4烷硫基、三氟甲基或硝基，R18、R19、R20和R21各自独立地为氢原子或甲基，k为0或1，I为0或1至3的整数）； R2 和 R3 各自独立地为氢原子、卤素原子或甲基； R4 是卤素原子或甲基； Rs 和 R6 各自独立地为氢原子、卤素原子、C1-C4 烷基、C1-C4 烷氧基、C1-C4 卤代烷基或 C1-C4 卤代烷氧基； X、Y 和 Z 各自独立地为氧原子、硫原子或亚甲基； m 是 0 或 1 至 4 的整数；以及 n 为 0 或 1 或 2 的整数，可用作杀虫剂。
• Liquid crystal compounds and intermediates thereof
  申请人：WAKO PURE CHEMICAL INDUSTRIES, LTD.

  公开号：EP0301587A1

  公开（公告）日：1989-02-01

  A liquid crystal compound of the formula: wherein m and n are independently integers of 1 to 22; k and t are independently integers of 1 or 2: and C* is an asymmetric carbon atom, is chemically stable and can be applied to liquid crystal display devices operable at room temperature.

  一种如下式的液晶化合物 其中 m 和 n 独立地为 1 至 22 的整数；k 和 t 独立地为 1 或 2 的整数；C* 为不对称碳原子，化学性质稳定，可用于可在室温下工作的液晶显示设备。