Amicetosemethylglykosid | 499213-79-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: Amicetosemethylglykosid
• 英文别名: 6-methoxy-2-methyl-tetrahydro-pyran-3-ol；D-Erythro-Hexopyranoside, methyl 2,3,6-trideoxy-, alpha-；6-methoxy-2-methyloxan-3-ol
• CAS: 499213-79-5
• 化学式: C₇H₁₄O₃
• 分子量: 146.186
• InChiKey: CWBJMXOKTZGNEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] PROCESS FOR PREPARATION OF NOVEL 42-0-(HETEROALKOXYALKYL) RAPAMYCIN COMPOUNDS WITH ANTI-PROLIFERATIVE PROPERTIES"<br/>[FR] PROCÉDÉ DE PRÉPARATION DE NOUVEAUX COMPOSÉS DE 42-O-(HÉTÉROALCOXYALKYL)RAPAMYCINE AYANT DES PROPRIÉTÉS ANTIPROLIFÉRATIVES
  申请人：MERIL LIFE SCIENCES PVT LTD

  公开号：WO2012017449A1

  公开（公告）日：2012-02-09

  The invention discloses novel 42-0-(heteroalkoxyalkyl) rapamycin compounds of formula (1) and process for preparation thereof. These compounds are useful in the treatment of hyperproliferative vascular diseases such as restenosis and atherosclerosis Wherein, R denotes 3, 4 and 5 membered 3-hydroxy heteroalkoxyalkyl compounds selected from Tetrahydrofuran-3-ol, Oxetan-3-ol, Tetrahydropyran-3-ol,Tetrahydro-4- methyl furan-3-ol, Tetrahydro-2,5,5-trimethyl furan-3-ol, Tetrahydro-2,5-diethyl-2- methyl furan-3-ol, Tetrahydro-6-methoxy-2-methyl 2H-Pyran-3-ol and Tetrahydro-2,2- dimethyl-6-phenyl 2H-Pyran-3-ol.

  本发明公开了一种新型的42-0-(杂代烷氧基烷基) 霉素化合物，其化学式为（1），以及其制备方法。这些化合物在治疗高增殖性血管疾病，如再狭窄和动脉粥样硬化方面具有用途。其中，R代表选自四氢呋喃-3-醇、氧杂环戊烷-3-醇、四氢吡喃-3-醇、四氢-4-甲基呋喃-3-醇、四氢-2,5,5-三甲基呋喃-3-醇、四氢-2,5-二乙基-2-甲基呋喃-3-醇、四氢-6-甲氧基-2-甲基-2H-吡喃-3-醇和四氢-2,2-二甲基-6-苯基-2H-吡喃-3-醇的3、4和5元杂代3-羟基烷氧基烷基化合物。
• PROCESS FOR PREPARATION OF NOVEL 42-0-(HETEROALKOXYALKYL) RAPAMYCIN COMPOUNDS WITH ANTI-PROLIFERATIVE PROPERTIES"
  申请人：Meril Life Sciences Pvt. Ltd.

  公开号：EP2601201B1

  公开（公告）日：2014-09-24
• JP2013536182A
  申请人：——

  公开号：JP2013536182A

  公开（公告）日：2013-09-19
• PROCESS FOR PREPARATION OF NOVEL 42-O-(HETEROALKOXYALKYL) RAPAMICIN COMPOUNDS WITH ANTI-PROLIFERATIVE PROPERTIES
  申请人：Rane Dhananjay Sharad

  公开号：US20130184305A1

  公开（公告）日：2013-07-18

  The invention discloses novel 42-0-(heteroalkoxyalkyl) rapamycin compounds of formula (1) and process for preparation thereof. These compounds are useful in the treatment of hyperproliferative vascular diseases such as restenosis and atherosclerosis Wherein, R denotes 3, 4 and 5 membered 3-hydroxy heteroalkoxyalkyl compounds selected from Tetrahydrofuran-3-ol, Oxetan-3-ol, Tetrahydropyran-3-ol, Tetrahydro-4- methyl furan-3-ol, Tetrahydro-2,5,5-trimethyl furan-3-ol, Tetrahydro-2,5-diethyl-2-methyl furan-3-ol, Tetrahydro-6-methoxy-2-methyl 2H-Pyran-3-ol and Tetrahydro-2,2-dimethyl-6-phenyl 2H-Pyran-3-ol.
• US9321782B2
  申请人：——

  公开号：US9321782B2

  公开（公告）日：2016-04-26