2,3-Dihydrothieno[2,3-b]pyridine 1,1-dioxide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并吡啶类
• 英文名称: 2,3-Dihydrothieno[2,3-b]pyridine 1,1-dioxide
• 化学式: C₇H₇NO₂S
• 分子量: 169.2
• InChiKey: XVGFBXSCSVELBT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  55.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-But-3-ynylsulfonylpyrimidine 以63%的产率得到
  参考文献：
  名称：

  FRISSEN, A. E.;MARCELIS, A. T. M.;VAN, DER PLAS H. C., TETRAHEDRON, 45,(1989) N, C. 803-812

  摘要：

  DOI：

文献信息

• N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS
  申请人：Rodgers James D.

  公开号：US20100298334A1

  公开（公告）日：2010-11-25

  The present invention relates to N-(hetero)aryl-pyrrolidine derivatives of Formula I: which are JAK inhibitors, such as selective JAK1 inhibitors, useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.

  本发明涉及式I的N-(杂)芳基吡咯烷衍生物： 这些是JAK抑制剂，如选择性JAK1抑制剂，在治疗JAK相关疾病方面具有用处，例如炎症和自身免疫性疾病，以及癌症。
• MODULATORS OF CELLULAR ADHESION
  申请人：SARcode Bioscience Inc.

  公开号：US20140066476A1

  公开（公告）日：2014-03-06

  The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R 1 -R 4 , n, p, A, B, D, E, L and AR 1 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders mediated by the CD11/CD18 family of cellular adhesion molecules (e.g., LFA-1).

  本发明提供具有以下式(I)的化合物及其药学上可接受的衍生物，其中R1-R4、n、p、A、B、D、E、L和AR1的描述通常在此处描述，并且此外还提供其制药组合物和用于治疗由CD11/CD18细胞粘附分子家族介导的疾​​病（例如LFA-1）的方法。
• HERBICIDE-METABOLIZING CYTOCHROME P450 MONOOXYGENASES
  申请人：BASF SE

  公开号：US20150322453A1

  公开（公告）日：2015-11-12

  The present invention refers to method for producing a transgenic plant with increased herbicide tolerance or resistance as compared to a corresponding non-transformed wild type plant, comprising transforming a plant cell or a plant cell nucleus or a plant tissue with a nucleic acid molecule encoding an Alopecurus cytochrome P450 monooxygenase, as well as to the nucleic acid, and plants with increased herbicide tolerance or resistance comprising the nucleic acid of the invention. Furthermore, the present invention refers to methods of controlling weeds at a locus which contains a plant with increased herbicide tolerance or resistance comprising the nucleic acid of the invention.

  本发明涉及一种制备转基因植物的方法，与相应的非转基因野生型植物相比，该方法可使转基因植物具有更高的除草剂耐受性或抗性，包括将植物细胞或植物细胞核或植物组织转化为编码Alopecurus细胞色素P450单加氧酶的核酸分子，以及包括本发明核酸的具有增强除草剂耐受性或抗性的植物。此外，本发明还涉及一种在含有具有增强除草剂耐受性或抗性的植物的基因座上控制杂草的方法，其中包括本发明核酸。
• Herbicide-metabolizing cytochrome P450 monooxygenases
  申请人：BASF SE

  公开号：US10294488B2

  公开（公告）日：2019-05-21

  The present invention refers to method for producing a transgenic plant with increased herbicide tolerance or resistance as compared to a corresponding non-transformed wild type plant, comprising transforming a plant cell or a plant cell nucleus or a plant tissue with a nucleic acid molecule encoding an Alopecurus cytochrome P450 monooxygenase, as well as to the nucleic acid, and plants with increased herbicide tolerance or resistance comprising the nucleic acid of the invention. Furthermore, the present invention refers to methods of controlling weeds at a locus which contains a plant with increased herbicide tolerance or resistance comprising the nucleic acid of the invention.

  本发明是指生产与相应的非转化野生型植物相比具有更强的除草剂耐受性或抗性的转基因植物的方法，包括用编码Alopecurus细胞色素P450单氧化酶的核酸分子以及核酸转化植物细胞或植物细胞核或植物组织，以及用包含本发明核酸的具有更强除草剂耐受性或抗性的植物转化植物细胞或植物细胞核或植物组织。此外，本发明还涉及在含有本发明核酸的具有更强除草剂耐受性或抗性的植物的基因座上控制杂草的方法。
• Herbicide-resistant hydroxyphenylpyruvate dioxygenases
  申请人：BASF SE

  公开号：US10619138B2

  公开（公告）日：2020-04-14

  The present invention refers to method for producing a transgenic plant with increased herbicide tolerance or resistance as compared to a corresponding non-transformed wild type plant, comprising transforming a plant cell or a plant cell nucleus or a plant tissue with a nucleic acid molecule encoding a HPPD polypeptide, as well as to the nucleic acid, and plants with increased HPPD-inhibiting herbicide tolerance or resistance comprising the nucleic acid of the invention.

  本发明是指生产与相应的非转化野生型植物相比具有更强除草剂耐受性或抗性的转基因植物的方法，包括用编码 HPPD 多肽的核酸分子转化植物细胞或植物细胞核或植物组织，以及用本发明的核酸转化具有更强 HPPD 抑制除草剂耐受性或抗性的植物。