methyl 4-hydroxyphenyllactate

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: methyl 4-hydroxyphenyllactate
• 英文别名: methyl p-hydroxyphenyllactate；Benzeneacetic acid, alpha,4-dihydroxy-alpha-methyl-, methyl ester；methyl 2-hydroxy-2-(4-hydroxyphenyl)propanoate
• 化学式: C₁₀H₁₂O₄
• 分子量: 196.203
• InChiKey: MVPSRTNYIXVQOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 4-hydroxyphenyllactate 、 溴乙酸叔丁酯 在 potassium carbonate 作用下， 以 N-甲基乙酰胺 为溶剂， 生成 methyl 4-(t-butoxycarbonylmethoxy)phenyllactate
  参考文献：
  名称：

  Alpha-substituted carboxylic acid derivatives

  摘要：

  具有如下式(I)的α-取代羧酸衍生物，其中R1是烷基基团，R2是氢原子，R3是氢原子，A是═CH-基团，B是氧原子，W1是C1-C8烷基基团，W2是单键或C1-C8烷基基团，X是氢原子，Y是氧原子，Z1是烷氧基团，其药理学上可接受的盐、酯和酰胺对于治疗和/或预防糖尿病、糖耐量受损、妊娠期糖尿病等疾病是有用的。其中一些具有如上式(I)的衍生物是新化合物。

  公开号：

  US20030069294A1

文献信息

• Novel chalcones
  申请人：——

  公开号：US20030055056A1

  公开（公告）日：2003-03-20

  The present invention discloses new and useful compounds including methyl p-hydroxyphenyllactate, its analogues, chemical derivatives and chemically related compounds and their use as antitumor and immune suppressive agents, as inhibitors of proliferative cell growth and as prophylactic agents to inhibit and prevent cancer and non-malignant cell growth.

  本发明揭示了新的有用化合物，包括甲基对羟基苯乳酸酯、其类似物、化学衍生物和化学相关化合物，以及它们作为抗肿瘤和免疫抑制剂、抑制增殖细胞生长的剂和预防癌症和非恶性细胞生长的预防剂的用途。
• Aromatic amino-alcohol derivatives having anti-diabetic and anti-obesity
  申请人：Sankyo Company, Limited

  公开号：US05635534A1

  公开（公告）日：1997-06-03

  Compounds of formula (I): ##STR1## (wherein: R.sup.0 is hydrogen, methyl or hydroxymethyl; R.sup.1 is substituted alkyl; R.sup.2 and R.sup.3 are each hydrogen, halogen, hydroxy, alkoxy, carboxy, alkoxycarbonyl, alkyl, nitro, haloalkyl, or substituted alkyl; X is oxygen or sulfur; and Ar optionally substituted phenyl or naphthyl); and pharmaceutically acceptable salts thereof have a variety of valuable pharmaceutical activities, including anti-diabetic and anti-obesity activities; in addition, they are capable of treating or preventing hyperlipemia and hyperglycemia and, by inhibiting the action of aldose reductase, they can also be effective in the treatment and prevention of complications of diabetes.

  式(I)的化合物：##STR1##（其中：R.sup.0为氢、甲基或羟甲基；R.sup.1为取代的烷基；R.sup.2和R.sup.3分别为氢、卤素、羟基、烷氧基、羧基、烷氧羰基、烷基、硝基、卤代烷基或取代的烷基；X为氧或硫；Ar为可选取代的苯基或萘基）；以及其药学上可接受的盐具有各种有价值的药理活性，包括抗糖尿病和抗肥胖活性；此外，它们能够治疗或预防高脂血症和高血糖症，并通过抑制醛固酮还原酶的作用，也可以在糖尿病并发症的治疗和预防中发挥作用。
• Chalcone coumarins
  申请人：——

  公开号：US20020161036A1

  公开（公告）日：2002-10-31

  The present invention discloses new and useful compounds including methyl p-hydroxyphenyllactate, its analogues, chemical derivatives and chemically related compounds and their use as antitumor and immune suppressive agents, as inhibitors of proliferative cell growth and as prophylactic agents to inhibit and prevent cancer and non-malignant cell growth.

  本发明揭示了新的有用化合物，包括甲基对羟基苯乳酸酯，其类似物，化学衍生物和化学相关化合物，以及它们作为抗肿瘤和免疫抑制剂，作为增殖细胞生长的抑制剂，以及作为预防和抑制癌症和非恶性细胞生长的预防剂的用途。
• &agr;-substituted carboxylic acid derivatives
  申请人：Sankyo Company Limited

  公开号：US06596751B2

  公开（公告）日：2003-07-22

  The &agr;-substituted carboxylic acid derivatives having the formula (I): wherein R1 is an alkyl group, etc., R2 is a hydrogen atom, etc., R3 is a hydrogen atom, etc., A is ═CH-group, etc., B is an oxygen atom, etc., W1 is a C1-C8 alkylene group, W2 is a single bond or a C1-C8 alkylene group, X is a hydrogen atom, etc., Y is an oxygen atom, etc., and Z1 is an alkoxy group, etc., and pharmacologically acceptable salts, esters and amides thereof are useful for treatment and/or prevention of diabetes mellitus, impaired glucose tolerance, gestational diabetes mellitus, or the like. Some of the derivatives of the formula (I) are novel compounds.

  具有以下式子（I）的α-取代羧酸衍生物：其中，R1是烷基，等等，R2是氢原子，等等，R3是氢原子，等等，A是═CH-基团，等等，B是氧原子，等等，W1是C1-C8烷基基团，W2是单键或C1-C8烷基基团，X是氢原子，等等，Y是氧原子，等等，Z1是烷氧基团，等等，以及其药学上可接受的盐、酯和酰胺，用于治疗和/或预防糖尿病、糖耐量受损、妊娠糖尿病等。其中，式子（I）的某些衍生物是新化合物。
• PROCESS FOR PRODUCING 1,2-ETHANEDIOL DERIVATIVES
  申请人：NITTO CHEMICAL INDUSTRY CO., LTD.

  公开号：EP0816316A1

  公开（公告）日：1998-01-07

  A process for preparing a 1,2-ethanediol derivative in a high yield by reducing an α-hydroxy carboxylic acid ester derivative in a protic solvent or a hydrous aprotic polar solvent in the presence of a sodium boron hydride compound. A process for preparing a 1,2-ethanediol derivative in a high yield by esterifying an α-hydroxy carboxylic acid derivative to synthesize an α-hydroxy carboxylic acid ester derivative, and reducing this ester derivative in a protic solvent or a hydrous aprotic polar solvent in the presence of a sodium borohydride compound in the same reaction vessel.

  一种在氢化硼钠化合物存在下，通过在原生溶剂或含水非丙烯极性溶剂中还原 α-羟基羧酸酯衍生物，以高产率制备 1，2-乙二醇衍生物的工艺。一种通过酯化α-羟基羧酸衍生物合成α-羟基羧酸酯衍生物，并在同一反应容器中，在有硼氢化钠化合物存在的情况下，在质子溶剂或含水非丙烷极性溶剂中还原该酯衍生物，从而高产率制备1，2-乙二醇衍生物的工艺。