Butyl-<2-aethoxy-aethyl>-amin | 29984-17-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Butyl-<2-aethoxy-aethyl>-amin
• 英文别名: N-(2-Ethoxyethyl)-1-butanamine；N-(2-ethoxyethyl)butan-1-amine
• CAS: 29984-17-6
• 化学式: C₈H₁₉NO
• mdl: MFCD01095845
• 分子量: 145.245
• InChiKey: XVJLXAOFCWJOCT-UHFFFAOYSA-N

物化性质

• 沸点：
  177-178 °C
• 密度：
  0.826±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  10
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Butyl-<2-aethoxy-aethyl>-amin 以80%的产率得到
  参考文献：
  名称：

  BANKS R.; BROOKES R. F.; GODSON D. H., J. CHEM. SOC. PERKIN TRANS. PART 1 , 1975, NO 19, 1836-1840

  摘要：

  DOI：
• 作为产物：
  描述：

  在 巯基乙酸 、 三乙胺 作用下， 以 乙酸乙酯 为溶剂， 反应 3.0h， 生成 Butyl-<2-aethoxy-aethyl>-amin
  参考文献：
  名称：

  Synthesis and pharmacological evaluation of 1,1,3-substituted urea derivatives as potent TNF-α production inhibitors

  摘要：

  A three substituted urea derivative, SA13353 (compound 1a), exhibited potent inhibitory activity against lipopolysaccharide (LPS)-induced TNF-alpha production. We focused on the 1,1-substituted moiety (R(1) and R(2)) of SA13353 and investigated substituent effects of this moiety on LPS-induced TNF-alpha production by oral administration in rats. The synthesis of the urea derivatives was performed rapidly in a one-pot manner using a manual synthesizer. Several compounds containing hydrophobic substituents at this moiety showed more potent inhibitory activities than SA13353. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.06.037

文献信息

• SYNTHESIS AND USES OF PEPTIDE BORATE ESTER COMPOUND
  申请人：Jiangsu Chia Tai Fenghai Pharmaceutical Co., Ltd.

  公开号：EP3805237A1

  公开（公告）日：2021-04-14

  Provided are a peptide borate ester compound or a pharmaceutically acceptable salt thereof, a preparation method therefor, and pharmaceutical use thereof. The peptide borate ester compound or pharmaceutically acceptable salt thereof has a structure as shown in Formula (I), and is useful in the preparation of proteasome inhibitors to treat solid tumors and hematoma.

  本文提供了一种肽硼酸酯化合物或其药学上可接受的盐、其制备方法及其药物用途。肽硼酸酯化合物或其药学上可接受的盐具有如式（I）所示的结构，可用于制备蛋白酶体抑制剂以治疗实体瘤和血肿。
• Banks,R. et al., Journal of the Chemical Society. Perkin transactions I, 1975, p. 1836 - 1840
  作者：Banks,R. et al.

  DOI：——

  日期：——
• (Nu.M; M = Li or MgX) β-.
  作者：G.W. Cooper、R.P. Houghton

  DOI：10.1016/s0040-4039(01)98623-x

  日期：1970.1
• Synthesis and pharmacological evaluation of 1,1,3-substituted urea derivatives as potent TNF-α production inhibitors
  作者：Hiroshi Enomoto、Ayako Sawa、Hiroshi Suhara、Noriyoshi Yamamoto、Hiroyuki Inoue、Chikako Setoguchi、Fumio Tsuji、Masahiro Okamoto、Yoshimasa Sasabuchi、Masato Horiuchi、Masakazu Ban

  DOI：10.1016/j.bmcl.2010.06.037

  日期：2010.8

  A three substituted urea derivative, SA13353 (compound 1a), exhibited potent inhibitory activity against lipopolysaccharide (LPS)-induced TNF-alpha production. We focused on the 1,1-substituted moiety (R(1) and R(2)) of SA13353 and investigated substituent effects of this moiety on LPS-induced TNF-alpha production by oral administration in rats. The synthesis of the urea derivatives was performed rapidly in a one-pot manner using a manual synthesizer. Several compounds containing hydrophobic substituents at this moiety showed more potent inhibitory activities than SA13353. (C) 2010 Elsevier Ltd. All rights reserved.
• BANKS R.; BROOKES R. F.; GODSON D. H., J. CHEM. SOC. PERKIN TRANS. PART 1 <JCPK-BH>, 1975, NO 19, 1836-1840
  作者：BANKS R.、 BROOKES R. F.、 GODSON D. H.

  DOI：——

  日期：——