2-methyl-1H,6H-pyrazolo<4,3-c>phenothiazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 2-methyl-1H,6H-pyrazolo<4,3-c>phenothiazine
• 英文别名: 2-methyl-6H-pyrazolo[4,3-c]phenothiazine
• 化学式: C₁₄H₁₁N₃S
• 分子量: 253.327
• InChiKey: HJQIGQQQGJPOBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  55.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-methyl-6-phenylamino-1H-indazole 在 碘 、 sulfur 作用下， 以 邻二氯苯 为溶剂， 反应 8.0h， 以55%的产率得到2-methyl-1H,6H-pyrazolo<4,3-c>phenothiazine
  参考文献：
  名称：

  Synthesis of Substituted Pyrazolo[3,4-b]- and Pyrazolo[4,3-c]phenothiazine Derivatives

  摘要：

  The synthesis of new pyrazolo[b]- and [c]phenothiazines by the Bernthsen thionation of N-arylindazoles obtained using organometalic compounds is reported.

  DOI：

  10.3987/com-94-6963

文献信息

• [EN] USE OF CONDENSED BENZO[B]THIAZINE DERIVATIVES AS CYTOPROTECTANTS<br/>[FR] UTILISATION DE DÉRIVÉS DE BENZO[B]THIAZINE EN TANT QU'AGENTS CYTOPROTECTEURS
  申请人：MEDEIA THERAPEUTICS LTD

  公开号：WO2014191632A1

  公开（公告）日：2014-12-04

  The present invention relates to arylthiazine compounds, metabolites, N-oxides, amides, esters,pharmaceutically acceptable salts, hydrates and solvates thereof and their use as cytoprotectants in the treatment or prophylaxis of diseases or states, either acute or chronic, involving aberrant cellular lipid peroxidation in the central nervous system or in the periphery of the body. The present invention also relates to a method for their preparation and to pharmaceutical composition comprising as an active ingredient one or more of the aforementioned compounds.

  本发明涉及芳基噻嗪化合物、代谢物、N-氧化物、酰胺、酯、药用可接受盐、水合物和溶剂合物，以及它们在治疗或预防涉及中枢神经系统或身体周围存在异常细胞脂质过氧化的疾病或状态中作为细胞保护剂的用途。本发明还涉及它们的制备方法以及包含作为活性成分的上述化合物之一或多个的药物组合物。
• USE OF CONDENSED BENZO[B]THIAZINE DERIVATIVES AS CYTOPROTECTANTS
  申请人：ARANDA PHARMA LTD

  公开号：US20160106754A1

  公开（公告）日：2016-04-21

  The present invention relates to arylthiazine compounds, metabolites, N-oxides, amides, esters,pharmaceutically acceptable salts, hydrates and solvates thereof and their use as cytoprotectants in the treatment or prophylaxis of diseases or states, either acute or chronic, involving aberrant cellular lipid peroxidation in the central nervous system or in the periphery of the body. The present invention also relates to a method for their preparation and to pharmaceutical composition comprising as an active ingredient one or more of the aforementioned compounds.

  本发明涉及芳基噻嗪化合物、代谢物、N-氧化物、酰胺、酯、药学上可接受的盐、水合物和溶剂化物，以及它们在治疗或预防涉及中枢神经系统或身体周围的异常细胞脂质过氧化的急性或慢性疾病或状态中作为细胞保护剂的用途。本发明还涉及一种它们的制备方法和包含上述化合物中的一个或多个作为活性成分的制药组合物。
• Boyer Gerard, Galy Jean Pierre, Barbe Jacques, Heterocycles, 41 (1995) N 3, S 487-496
  作者：Boyer Gerard, Galy Jean Pierre, Barbe Jacques

  DOI：——

  日期：——
• US9827249B2
  申请人：——

  公开号：US9827249B2

  公开（公告）日：2017-11-28
• Synthesis of Substituted Pyrazolo[3,4-b]- and Pyrazolo[4,3-c]phenothiazine Derivatives
  作者：Gérard Boyer、Jean Pierre Galy、Jacques Barbe

  DOI：10.3987/com-94-6963

  日期：——

  The synthesis of new pyrazolo[b]- and [c]phenothiazines by the Bernthsen thionation of N-arylindazoles obtained using organometalic compounds is reported.

表征谱图