N-(5-tert-butyl-4-methyl-1,3-thiazol-2-yl)acetamide

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(5-tert-butyl-4-methyl-1,3-thiazol-2-yl)acetamide
• 化学式: C₁₀H₁₆N₂OS
• 分子量: 212.31
• InChiKey: FYVVXDVXJGORDW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  70.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Inhibitors of phosphatidylinositol 3-kinase gamma
  申请人：AstraZeneca AB

  公开号：US10858355B2

  公开（公告）日：2020-12-08

  There are disclosed certain novel compounds (including pharmaceutically acceptable salts thereof), that inhibit phosphatidylinositol 3-kinase gamma (PI3Kδ) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

  本文公开了某些新型化合物（包括其药学上可接受的盐）、 抑制磷脂酰肌醇 3- 激酶γ（PI3Kδ）活性的化合物，它们在治疗和/或预防包括呼吸系统疾病（如哮喘和慢性阻塞性肺病（COPD））在内的临床疾病中的用途，它们在治疗中的使用，含有它们的药物组合物，以及制备此类化合物的工艺。
• COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP2217565B1

  公开（公告）日：2013-05-22
• SULFONYL COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR
  申请人：Hickey Eugene Richard

  公开号：US20130184315A1

  公开（公告）日：2013-07-18

  Compounds of formula (I) and formula (II) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
• PYRIDINO[1,2-A]PYRIMIDONE ANALOGUE USED AS P13K INHIBITOR
  申请人：CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

  公开号：US20170137420A1

  公开（公告）日：2017-05-18

  Disclosed is a pyridino[1,2-a]pyrimidone analogue used as a PI3K inhibitor. The present invention particularly relates to a compound represented by formula (I) or a pharmaceutically acceptable salt thereof.
• PYRIDINO[1,2-A]PYRIMIDONE ANALOGUE USED AS MTOR/P13K INHIBITOR
  申请人：CISEN PHARMACEUTICAL CO., LTD.

  公开号：US20170129888A1

  公开（公告）日：2017-05-11

  Disclosed is a pyridino[1,2-a]pyrimidone analogue used as an mTOR/PI3K inhibitor. The present invention particularly relates to a compound represented by formula (I) or a pharmaceutically acceptable salt thereof.