2-methyl-4-phenyl-4-piperidino-1-butene | 1082512-40-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-methyl-4-phenyl-4-piperidino-1-butene
• 英文别名: 1-(3-Methyl-1-phenylbut-3-enyl)piperidine
• CAS: 1082512-40-0
• 化学式: C₁₆H₂₃N
• 分子量: 229.365
• InChiKey: MIZBBMHBMJCNIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-溴-2-甲基丙烯 、 1-(苯基-哌啶-1-基甲基)哌啶 在 三甲基氯硅烷 、 二异丙胺 、 锌 作用下， 以 苯 为溶剂， 反应 6.0h， 以82%的产率得到2-methyl-4-phenyl-4-piperidino-1-butene
  参考文献：
  名称：

  Zinc-Mediated Allylation and Alkylation of Aminals in the Presence of TMSCl and Diisopropylamine

  摘要：

  An alkylation of aminals with organozinc reagents derived from allyl bromide, benzyl bromide, alpha-bromoacetate, and alpha-bromonitrile proceeded efficiently in the presence of TMSCl and diisopropylamine. This reaction system was applied to the synthesis of an antispasmodic: butaverine.

  DOI：

  10.1021/jo8019797

文献信息

• Allylation of N,N-Acetal Derivatives Using Allyl Tin Regent in the Presence of Aluminum Chloride
  作者：Bunpei Hatano、Xiaonan Sun、Takanori Obu、Tatsuro Kijima、Satoshi Murakami、Shigeru Matsuba

  DOI：10.3987/com-13-12845

  日期：——

  Allylation of N,N-acetal derivatives proceeded efficiently using allyl tin regent in the presence of aluminum chloride, giving homoallylamines in good yields. This allylation was applied for N,S-acetals to give the corresponding homoallylamines.
• Zinc-Mediated Allylation and Alkylation of Aminals in the Presence of TMSCl and Diisopropylamine
  作者：Bunpei Hatano、Keita Nagahashi、Tatsuro Kijima

  DOI：10.1021/jo8019797

  日期：2008.11.21

  An alkylation of aminals with organozinc reagents derived from allyl bromide, benzyl bromide, alpha-bromoacetate, and alpha-bromonitrile proceeded efficiently in the presence of TMSCl and diisopropylamine. This reaction system was applied to the synthesis of an antispasmodic: butaverine.