N-[(2,4-dihydroxyphenyl)methylideneamino]-4-fluorobenzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: N-[(2,4-dihydroxyphenyl)methylideneamino]-4-fluorobenzamide
• 化学式: C₁₄H₁₁FN₂O₃
• mdl: MFCD00424319
• 分子量: 274.251
• InChiKey: TZZVVMMGGVAUHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  81.9
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  thorium(IV) nitrate 、 N-[(2,4-dihydroxyphenyl)methylideneamino]-4-fluorobenzamide 以 乙醇 、 水 为溶剂， 生成
  参考文献：
  名称：

  酰腙作为敏感荧光传感器，用于从铀酰和镧系离子中鉴别检测钍 (IV)

  摘要：

  钍作为一种放射性元素，在自然界中总是与稀土伴生在一起。因此，由于镧系离子的离子半径重叠，因此在镧系离子存在的情况下识别钍离子 (Th 4+ ) 是一项严峻的挑战。这里探索了三种简单的酰腙（AF、AH和ABr，分别具有氟、氢和溴官能团）用于 Th 4+检测。它们都对水介质中的f区离子中的Th 4+表现出优异的“开启”荧光选择性，具有出色的抗干扰能力，其中镧系元素和铀酰离子以及其他普通金属离子的共存在Th期间的影响可以忽略不计4+检测。有趣的是，从 2 到 11 的 pH 变化对检测没有显着影响。在这三种传感器中，AF对 Th 4+的灵敏度最高，而ABr的灵敏度最低，发射波长的顺序为 λ AF -Th  < λ AH -Th  < λ ABr -Th。AF对Th 4+的检测限可达29 nM (pH = 2)，结合常数为6.64 × 10 9 M −2。基于 HR-MS 的结果提出了AF对 Th

  DOI：

  10.1016/j.saa.2023.122501
• 作为产物：
  描述：

  4-氟苯甲酰肼 、 2,4-二羟基苯甲醛 以 甲醇 为溶剂， 生成 N-[(2,4-dihydroxyphenyl)methylideneamino]-4-fluorobenzamide
  参考文献：
  名称：

  A facile accessible acylhydrazone as Al3+ sensor with excellent sensitivity and selectivity

  摘要：

  As Al3+ is detrimental both to human and other organisms, a simple sensor, acylhydrazone AhzF, is synthesized in one step and its structure is confirmed by single crystal X-ray diffraction. AhzF shows specific fluorescence turn-on response for Al3+ over other metal ions at UV 365 nm, observed by naked-eyes. Its detection limit can reach to 1.11 x 10(-9) M in ethanol. Meanwhile, AhzF at low concentration can detect Al3+ with excellent interference resistance to typical disturbing metal ions including Cu2+ and Fe3+. For the first time, concentration influence of Fe3+ during AhzF detecting Al3+ has been explored and it has been found that the fluorescence of AhzF-Al3+ is partly quenched by Fe3+ while with no influence by Cu2+ at high concentration (above 10(-6) M), indicating its good low concentration advantage during Al3+ detection. The binding mode exhibits a 1:1M ratio between AhzF and Al3+, which are confirmed by titration test, Job's plot, H-1 NMR spectra and mass spectrum. It also exhibits good reusability by alternate addition of Al3+ and EDTA to the AhzF solution. The pH effect tests suggest its good sensitivity from pH 4 to pH 10 and AhzF can recognize labeled Al3+ in tap water directly by naked eyes, which makes it possible for the application in real environment. (C) 2019 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molstruc.2019.127155