2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-methylbenzyl)acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-methylbenzyl)acetamide
• 英文别名: 2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-N-[(4-methylphenyl)methyl]acetamide
• 化学式: C₁₇H₁₉N₅O₃
• mdl: MFCD01993491
• 分子量: 341.4
• InChiKey: ZQYUBEAVHBKVJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  87.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL
  申请人：Hydra Biosciences, Inc.

  公开号：EP3184527A1

  公开（公告）日：2017-06-28

  Compounds of formula (VIII) and compositions for treating disorders related to TRPA1 are described herein.

  本文描述了式（VIII）化合物和用于治疗 TRPA1 相关疾病的组合物。
• METHODS OF INSECT CONTROL
  申请人：Garrity Paul

  公开号：US20110151018A1

  公开（公告）日：2011-06-23

  The present invention is directed towards methods of inhibiting thermo- and chemo-sensing in insects and pests by inhibiting TRPA1 ion gated channel or family members. The present invention is also directed towards methods of insect control by modulating the TRPA1 ion gated channel or family members. The methods are applicable to a wide variety of insects and pests including agricultural and horticultural pests.