methyl 3-[4-ethyl(3-methoxy-3-oxopropyl)anilino]propanoate | 1226353-96-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: methyl 3-[4-ethyl(3-methoxy-3-oxopropyl)anilino]propanoate
• 英文别名: methyl 3-(4-ethyl-N-(3-methoxy-3-oxopropyl)anilino)propanoate
• CAS: 1226353-96-3
• 化学式: C₁₆H₂₃NO₄
• 分子量: 293.363
• InChiKey: XAVTXYZXGWLBFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.18
• 重原子数：
  21.0
• 可旋转键数：
  8.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  55.84
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  丙烯酸甲酯（MA） 、 4-乙基苯胺 在 aluminum oxide 作用下， 反应 3.0h， 以87%的产率得到methyl 3-(4-ethylanilino)propanoate
  参考文献：
  名称：

  Aza-Michael reaction: selective mono- versus bis-addition under environmentally-friendly conditions

  摘要：

  Aza-Michael reactions between primary amines and methyl propenoate have been investigated under environmentally-friendly solventless heterogeneous catalysis in order to obtain the mono- or the bis-adduct. The reaction conditions can be altered so as to maximise the yields of the required product with high selectivity. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.02.021

文献信息

• Aza-Michael reaction: selective mono- versus bis-addition under environmentally-friendly conditions
  作者：Giovanna Bosica、Jonathan Spiteri、Caroline Borg

  DOI：10.1016/j.tet.2014.02.021

  日期：2014.4

  Aza-Michael reactions between primary amines and methyl propenoate have been investigated under environmentally-friendly solventless heterogeneous catalysis in order to obtain the mono- or the bis-adduct. The reaction conditions can be altered so as to maximise the yields of the required product with high selectivity. (C) 2014 Elsevier Ltd. All rights reserved.