N-(2-methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)-1-benzofuran-2-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: N-(2-methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)-1-benzofuran-2-carboxamide
• 英文别名: N-(2-methyl-1,3-dioxoisoindol-5-yl)-1-benzofuran-2-carboxamide
• 化学式: C₁₈H₁₂N₂O₄
• 分子量: 320.3
• InChiKey: DXEWCLOMLCYAEG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  79.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Anti-proprotein convertase subtilisin kexin type 9 (anti-PCSK9) compounds and methods of using the same in the treatment and/or prevention of cardiovascular diseases
  申请人：Shifa Biomedical Corporation

  公开号：US10947220B2

  公开（公告）日：2021-03-16

  Disclosed are compounds that modulate the physiological action of the proprotein convertase subtilisin kexin type 9 (PCSK9), as well as therapeutic methods for use of such compounds to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease (CVD), including treatment of hypercholesterolemia.

  所公开的是调节9型（PCSK9）蛋白转换酶的生理作用的化合物，以及使用此类化合物降低低密度脂蛋白胆固醇水平和/或治疗和/或预防心血管疾病（CVD）（包括治疗高胆固醇血症）的治疗方法。
• Anti-Proprotein Convertase Subtilisin Kexin Type 9 (Anti-PCSK9) Compounds and Methods of Using the Same in the Treatment and/or Prevention of Cardiovascular Diseases
  申请人：Shifa Biomedical Corporation

  公开号：US20190270729A1

  公开（公告）日：2019-09-05

  Disclosed are compounds that modulate the physiological action of the proprotein convertase subtilisin kexin type 9 (PCSK9), as well as therapeutic methods for use of such compounds to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease (CVD), including treatment of hypercholesterolemia.