5-异丙基-1,3,5-二恶嗪烷 | 224791-28-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 5-异丙基-1,3,5-二恶嗪烷
• 英文名称: 5-isopropyl-1,3,5-dioxazine
• 英文别名: 5-isopropyl-1,3,5-dioxazacyclohexane；5-Propan-2-yl-1,3,5-dioxazinane
• CAS: 224791-28-0
• 化学式: C₆H₁₃NO₂
• 分子量: 131.175
• InChiKey: MUJOZIPWAWHPGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-异丙基-1,3,5-二恶嗪烷 在 硼烷四氢呋喃络合物 作用下， 以 四氢呋喃 为溶剂， 反应 0.08h， 以85%的产率得到5-Isopropyl-[1,3,5]dioxazinane; compound with borane
  参考文献：
  名称：

  1,3,5-二噻氮杂-、-二恶氮杂-、-噻二氮杂-和-三氮杂环己烷的硼烷和氯硼烷加合物及其重排产物、硼环己烷的结构分析

  摘要：

  1,3,5-杂环己烷的硼烷和氯硼烷加合物及其重排产物硼环己烷的 1H-、11B-、13C-、二维和变温 NMR 光谱进行了结构和构象研究。N-甲基衍生物产生赤道N-硼烷加合物，而N-异丙基衍生物产生轴向硼烷化合物。加合物的重排反应给出了带有硼和氮原子作为稳定立体中心的氯硼环己烷的第一个例子。发现 BClH2 和 BCl2H 加合物对环重排比相应的 N-BH3 类似物更稳定。

  DOI：

  10.1002/(sici)1099-0682(199911)1999:11<2063::aid-ejic2063>3.0.co;2-a
• 作为产物：
  描述：

  聚合甲醛 、 异丙胺 以 水 为溶剂， 反应 12.0h， 以90%的产率得到5-异丙基-1,3,5-二恶嗪烷
  参考文献：
  名称：

  New 1,3,5-Heterocyclohexanes: Dioxazines, Oxadiazines, Thiadiazines, Oxathiazines and Triazines and Their Amination, Transamination and Disproportionation Reactions

  摘要：

  DOI：

  10.3987/com-99-8583

文献信息

• Multifunctionalized polyethylene glycol derivative and preparation method therefor
  申请人：XIAMEN SINOPEG BIOTECH CO., LTD.

  公开号：US11324827B2

  公开（公告）日：2022-05-10

  Disclosed are a multifunctionalized polyethylene glycol derivative and a preparation method therefor. The derivative has an H-shaped structure as represented by formula (1) and comprises one linear core LPEG and four PEG branch chains, where n1, n2, n3, and n4 respectively are the degrees of polymerization of the branch chains, U1 and U2 are trivalent branching groups connecting the core LPEG to two of the PEG branch chains, F1 and F2 contain a functional group or a protected form R01 thereof and may or may not contain a branched group G, correspondingly, the number of R01 is one or more, F1 and F2 are either identical or different, any one linking group in the molecule or any linking group formed with an adjacent heteroatom group can either remain stable or be degraded, and any one PEG segment in the molecule is discretely polydispersed or monodispersed. The multifunctional polyethylene glycol is flexible and diverse in terms of branch structures and the lengths of branching arms, has various parameters and performance indicators that are adjustable and easy to control, and has a broad applicability.

  本发明公开了一种多功能聚乙二醇衍生物及其制备方法。该衍生物具有由式（1）表示的 H 型结构，包括一个线性核心 LPEG 和四个 PEG 支链，其中 n1、n2、n3 和 n4 分别为支链的聚合度，U1 和 U2 为连接核心 LPEG 和两个 PEG 支链的三价支化基团、F1 和 F2 含有一个官能团或其保护形式 R01，可以含有或不含有支链基团 G，相应地，R01 的数目为一个或多个，F1 和 F2 要么相同要么不同，分子中的任何一个连接基团或与相邻杂原子基团形成的任何连接基团要么保持稳定，要么降解，分子中的任何一个 PEG 段离散多分散或单分散。多功能聚乙二醇的支链结构和支臂长度灵活多样，各种参数和性能指标可调且易于控制，具有广泛的适用性。
• MULTIFUNCTIONALIZED POLYETHYLENE GLYCOL DERIVATIVE AND PREPARATION METHOD THEREFOR
  申请人：XIAMEN SINOPEG BIOTECH CO., LTD.

  公开号：US20170312363A1

  公开（公告）日：2017-11-02

  Disclosed are a multifunctionalized polyethylene glycol derivative and a preparation method therefor. The derivative has an H-shaped structure as represented by formula (1) and comprises one linear core LPEG and four PEG branch chains, where n 1 , n 2 , n 3 , and n 4 respectively are the degrees of polymerization of the branch chains, U 1 and U 2 are trivalent branching groups connecting the core LPEG to two of the PEG branch chains, F 1 and F 2 contain a functional group or a protected form R 01 thereof and may or may not contain a branched group G, correspondingly, the number of R 01 is one or more, F 1 and F 2 are either identical or different, any one linking group in the molecule or any linking group formed with an adjacent heteroatom group can either remain stable or be degraded, and any one PEG segment in the molecule is discretely polydispersed or monodispersed. The multifunctional polyethylene glycol is flexible and diverse in terms of branch structures and the lengths of branching arms, has various parameters and performance indicators that are adjustable and easy to control, and has a broad applicability.