N-(1-oxo-3,4-dihydro-2H-naphthalen-2-yl)cyclopropanecarboxamide | 68942-86-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: N-(1-oxo-3,4-dihydro-2H-naphthalen-2-yl)cyclopropanecarboxamide
• CAS: 68942-86-9
• 化学式: C₁₄H₁₅NO₂
• 分子量: 229.279
• InChiKey: KAVWKKURXAJDCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(1-oxo-3,4-dihydro-2H-naphthalen-2-yl)cyclopropanecarboxamide 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 生成 (1R,2R)-2-(cyclopropylmethylamino)-1-phenyl-3,4-dihydro-2H-naphthalen-1-ol
  参考文献：
  名称：

  Aminotetralins as narcotic antagonists. Synthesis and opiate-related activity of 1-phenyl-1-aminotetralin derivatives

  摘要：

  The synthesis and the opiate agonist and antagonist activities of three derivatives of cis-2-[methyl(cyclopropanemethyl)amino]-1-phenyltetralin are reported. The compounds were obtained by synthetic modification from 2-amino-1-tetralone. The 1-propionoxy derivative 4c shows analgetic activity (ED50 = 17.8 mg/kg) one-half that of codeine, and the 1-methoxy derivative 4b has weak antagonist activity (AD50 = 33.5 mg/kg). The compounds showed no other significant opiate-related activity.

  DOI：

  10.1021/jm00188a017
• 作为产物：
  描述：

  2-氨基-3,4-二氢-1(2H)-萘酮盐酸盐(1:1) 生成 N-(1-oxo-3,4-dihydro-2H-naphthalen-2-yl)cyclopropanecarboxamide
  参考文献：
  名称：

  REIFENRATH W. G.; FRIES D. S., J. MED. CHEM., 1979, 22, NO 2, 204-206

  摘要：

  DOI：

文献信息

• Aminotetralins as narcotic antagonists. Synthesis and opiate-related activity of 1-phenyl-1-aminotetralin derivatives
  作者：William G. Reifenrath、David S. Fries

  DOI：10.1021/jm00188a017

  日期：1979.2

  The synthesis and the opiate agonist and antagonist activities of three derivatives of cis-2-[methyl(cyclopropanemethyl)amino]-1-phenyltetralin are reported. The compounds were obtained by synthetic modification from 2-amino-1-tetralone. The 1-propionoxy derivative 4c shows analgetic activity (ED50 = 17.8 mg/kg) one-half that of codeine, and the 1-methoxy derivative 4b has weak antagonist activity (AD50 = 33.5 mg/kg). The compounds showed no other significant opiate-related activity.
• REIFENRATH W. G.; FRIES D. S., J. MED. CHEM., 1979, 22, NO 2, 204-206
  作者：REIFENRATH W. G.、 FRIES D. S.

  DOI：——

  日期：——