6-methoxytetralone semicarbazone | 57700-25-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 6-methoxytetralone semicarbazone
• 英文别名: 6-methoxy-3,4-dihydro-2H-naphthalen-1-one semicarbazone；6-Methoxy-3,4-dihydro-2H-naphthalin-1-on-semicarbazon；[(6-methoxy-3,4-dihydro-2H-naphthalen-1-ylidene)amino]urea
• CAS: 57700-25-1
• 化学式: C₁₂H₁₅N₃O₂
• mdl: MFCD02087368
• 分子量: 233.27
• InChiKey: GRXIUDITOYZBLN-UHFFFAOYSA-N

物化性质

• 密度：
  1.31±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-methoxytetralone semicarbazone 在 sodium bismuthate 、 silica gel 作用下， 反应 0.13h， 以73%的产率得到6-甲氧基-1-萘满酮
  参考文献：
  名称：

  Regeneration of Ketones from Semicarbazones in the Solid State on Wet Silica Supported Sodium Bismuthate under Microwave Irradiation

  摘要：

  在无溶剂环境友好条件下，酮半卡巴脎在湿硅胶负载的钠铋酸盐上进行微波辐照，提供了一种快速、高效且简便的酮类化合物再生方法，且产率良好。

  DOI：

  10.1039/a806876c
• 作为产物：
  描述：

  4-(3-甲氧基苯基)丁酸 在 硫酸 作用下， 生成 6-methoxytetralone semicarbazone
  参考文献：
  名称：

  329.烷基萘取代反应中的取向。第二部分。1-甲基萘的硝化

  摘要：

  DOI：

  10.1039/jr9320002310

文献信息

• POTENTIAL NITROGEN-HETEROCYCLE CARCINOGENS. VI. POLY-SUBSTITUTED 1,2-BENZOCARBAZOLES, 1,2,5,6- AND 1,2,7,8-DIBENZOCARBAZOLES¹
  作者：NG. PH. BUU-HOÏ、PAUL CAGNIANT、NG. HOÁN、NG. H. KHÔI

  DOI：10.1021/jo01151a005

  日期：1950.9
• DE397150
  申请人：——

  公开号：——

  公开（公告）日：——
• Maiti, S. B.; Chatterjee, Amareshwar; Raychaudhuri, S. R., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1984, vol. 23, # 3, p. 203 - 205
  作者：Maiti, S. B.、Chatterjee, Amareshwar、Raychaudhuri, S. R.

  DOI：——

  日期：——
• Oral Arginine Reduces Systemic Blood Pressure in Type 2 Diabetes: Its Potential Role in Nitric Oxide Generation
  作者：Nhan T. Huynh、John A. Tayek

  DOI：10.1080/07315724.2002.10719245

  日期：2002.10

  Objectives: Arginine is converted in the endothelial cells to nitric oxide (NO) and citrulline. NO is a potent vasodilator in humans, but diabetics may have a reduced generation of NO which results in endothelial dysfunction. The aim of this study was to evaluate the effects of oral arginine on nitric oxide production, counter-regulatory hormones and blood pressure in mildly hypertensive type 2 diabetic patients.Methods: A prospective, crossover clinical trial was performed over a three-day stay in the General Clinical Research Center. Six patients with type 2 diabetes mellitus and mild hypertension consented and were given orally three grams of arginine per hour for 10 hours on either day 2 or day 3. On both days 2 and 3, blood pressure was monitored between 5 AM and 4 PM and mean pressure determined.Results: Oral arginine increased plasma citrulline from 31.3 +/- 6.0 to 41.5 +/- 6.0 mumol/L (mean +/- SEM; p < 0.05) which may reflect an increased conversion of arginine into NO and citrulline. Arginine reduced systolic BP from 135 +/- 7 to 123 +/- 8 mmHg; p < 0.05. Diastolic BP fell from 86.9 +/- 1.7 to 80.7 +/- 2.4 mmHg; p < 0.05). The reduction in BP was noted to occur two hours after starting oral arginine, and BP returned to normal within one hour of stopping the arginine. The oral arginine had no effect on C-peptide, insulin or other hormone concentrations.Conclusions: These data suggest that oral arginine may increase endothelial nitric oxide synthase (NOS) to increase vascular NO and temporally reduce blood pressure in mildly hypertensive type 2 diabetic patients.
• Selenium heterocycles. XVI. 1,2,3-Selenadiazolyl derivatives of polycyclic aromatic compounds and steroids
  作者：H. Golgolab、I. Lalezari

  DOI：10.1002/jhet.5570120442

  日期：1975.8