cis-dehydromatricaria lactone | 14686-19-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 英文名称: cis-dehydromatricaria lactone
• 英文别名: (Z)-dehydromatricaria lactone；(Z)-5-(hexa-2,4-diyn-1-ylidene)furan-2(5H)-one；Dehydromatricaria-lacton；2(5H)-Furanone,4-hexadiynylidene)-；(5Z)-5-hexa-2,4-diynylidenefuran-2-one
• CAS: 14686-19-2
• 化学式: C₁₀H₆O₂
• 分子量: 158.156
• InChiKey: YOTOGBLIOFSWLS-TWGQIWQCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (Z)-2,4-hexadiynyliden-1,6-dioxaspiro-<4.4>nona-2,8-dien-4-ol 在 manganese(IV) oxide 作用下， 以 乙醚 为溶剂， 反应 4.0h， 以3 mg的产率得到cis-dehydromatricaria lactone
  参考文献：
  名称：

  Acetylenes from the roots of Solidago species

  摘要：

  Roots of six Solidago species were examined for their content of acetylenes. The E and Z isomer of dehydromatricaria ester, (Z,Z)-matricaria ester, (Z)-dehydromatricaria lactone and a C-16-acetylene were isolated and identified. The Z and E isomer of dehydromatricaria lactone were furthermore produced by oxidation of 2,4-hexadiynyliden-1,6-dioxaspiro-[4.4]nona-2,8-dien-4-ol with activated MnO2.

  DOI：

  10.1016/0031-9422(92)80433-f

文献信息

• PDIA4 PROTEIN AS A TARGET FOR DIAGNOSIS, MONITORING AND TREATMENT OF DIABETES
  申请人：ACADEMIA SINICA

  公开号：US20170049794A1

  公开（公告）日：2017-02-23

  A Pdia4 inhibitor for use in preventing, alleviating and/or treating diabetes and/or diabetes-related complications in a subject in need thereof is disclosed, wherein the Pdia4 inhibitor does not comprise cytopiloyene. A Pdia4 inhibitor and one other anti-diabetic agent for use in combination therapy in preventing, alleviating, treating diabetes and diabetes-related complications, and/or reversing diabetes in a subject in need thereof is also disclosed, wherein the Pdia4 inhibitors for use in combination therapy may comprise cytopiloyene. Also disclosed are methods for diagnosing, treating and monitoring diabetes, and methods of screening for a Pdia4 inhibitor and/or an anti-diabetic agent.
• Acetylenes from the roots of Solidago species
  作者：Jørgen Lam、Lars P. Christensen、Thyge Färch、Tove Thomasen

  DOI：10.1016/0031-9422(92)80433-f

  日期：1992.12

  Roots of six Solidago species were examined for their content of acetylenes. The E and Z isomer of dehydromatricaria ester, (Z,Z)-matricaria ester, (Z)-dehydromatricaria lactone and a C-16-acetylene were isolated and identified. The Z and E isomer of dehydromatricaria lactone were furthermore produced by oxidation of 2,4-hexadiynyliden-1,6-dioxaspiro-[4.4]nona-2,8-dien-4-ol with activated MnO2.