tert-butyl N-[(3S,5R)-1-[6-[(3S,5R)-3,5-bis[(2-methylpropan-2-yl)oxycarbonylamino]piperidin-1-yl]-2-chloro-7H-purin-8-yl]-5-[(2-methylpropan-2-yl)oxycarbonylamino]piperidin-3-yl]carbamate | 849161-12-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: tert-butyl N-[(3S,5R)-1-[6-[(3S,5R)-3,5-bis[(2-methylpropan-2-yl)oxycarbonylamino]piperidin-1-yl]-2-chloro-7H-purin-8-yl]-5-[(2-methylpropan-2-yl)oxycarbonylamino]piperidin-3-yl]carbamate
• CAS: 849161-12-2
• 化学式: C₃₅H₅₇ClN₁₀O₈
• 分子量: 781.353
• InChiKey: FZEXNKFROUUPRT-COPRSSIGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  54
• 可旋转键数：
  14
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  214
• 氢给体数：
  5
• 氢受体数：
  13

反应信息

• 作为反应物：
  描述：

  tert-butyl N-[(3S,5R)-1-[6-[(3S,5R)-3,5-bis[(2-methylpropan-2-yl)oxycarbonylamino]piperidin-1-yl]-2-chloro-7H-purin-8-yl]-5-[(2-methylpropan-2-yl)oxycarbonylamino]piperidin-3-yl]carbamate 、 对苯二胺 反应 0.5h， 生成 di-tert-butyl ((3R,5S)-1-(2-((4-aminophenyl)amino)-6-((3R,5S)-3,5-bis((tert-butoxycarbonyl)amino)piperidin-1-yl)-9H-purin-8-yl)piperidine-3,5-diyl)dicarbamate
  参考文献：
  名称：

  Antibacterial activity in serum of the 3,5-diamino-piperidine translation inhibitors

  摘要：

  Translation inhibitors of the 3,5-diamino-piperidine series act as aminoglycoside mimetics that inhibit bacterial growth. Here we show antibacterial SAR in the presence and absence of serum with a particular focus toward Pseudomonas aeruginosa. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.04.023
• 作为产物：
  描述：

  di-tert-butyl ((3R,5S)-1-(8-bromo-2-chloro-9H-purin-6-yl)piperidine-3,5-diyl)dicarbamate 在 N-甲基吡咯烷酮 作用下， 反应 0.5h， 生成 tert-butyl N-[(3S,5R)-1-[6-[(3S,5R)-3,5-bis[(2-methylpropan-2-yl)oxycarbonylamino]piperidin-1-yl]-2-chloro-7H-purin-8-yl]-5-[(2-methylpropan-2-yl)oxycarbonylamino]piperidin-3-yl]carbamate 、 di-tert-butyl ((3R,5S)-1-(6-((3R,5S)-3,5-bis((tert-butoxycarbonyl)amino)piperidin-1-yl)-8-bromo-9H-purin-2-yl)piperidine-3,5-diyl)dicarbamate
  参考文献：
  名称：

  Antibacterial activity in serum of the 3,5-diamino-piperidine translation inhibitors

  摘要：

  Translation inhibitors of the 3,5-diamino-piperidine series act as aminoglycoside mimetics that inhibit bacterial growth. Here we show antibacterial SAR in the presence and absence of serum with a particular focus toward Pseudomonas aeruginosa. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.04.023

文献信息

• Antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds
  申请人：Zhou Yuefen

  公开号：US20070197533A1

  公开（公告）日：2007-08-23

  The invention relates to antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds and pharmaceutical compositions thereof. This invention also relates to a method of using such compounds in the treatment of bacterial infections in mammals, especially humans.

  本发明涉及抗菌性3,5-二氨基哌啶取代的芳香和杂环化合物及其制药组合物。本发明还涉及使用这些化合物治疗哺乳动物（尤其是人类）细菌感染的方法。
• US7223759B2
  申请人：——

  公开号：US7223759B2

  公开（公告）日：2007-05-29
• Antibacterial activity in serum of the 3,5-diamino-piperidine translation inhibitors
  作者：Yuefen Zhou、Chun Chow、Douglas E. Murphy、Zhongxiang Sun、Thomas Bertolini、Jamie M. Froelich、Stephen E. Webber、Thomas Hermann、Daniel Wall

  DOI：10.1016/j.bmcl.2008.04.023

  日期：2008.6

  Translation inhibitors of the 3,5-diamino-piperidine series act as aminoglycoside mimetics that inhibit bacterial growth. Here we show antibacterial SAR in the presence and absence of serum with a particular focus toward Pseudomonas aeruginosa. (C) 2008 Elsevier Ltd. All rights reserved.