2-[(2-Chlorobenzoyl)amino]-4-thiophen-2-ylthiophene-3-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 双噻吩和低聚噻吩
• 英文名称: 2-[(2-Chlorobenzoyl)amino]-4-thiophen-2-ylthiophene-3-carboxylic acid
• 化学式: C₁₆H₁₀ClNO₃S₂
• 分子量: 363.8
• InChiKey: FKZCOXZVRMRRKA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  123
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM
  申请人：Velicelebi Gonul

  公开号：US20100056532A1

  公开（公告）日：2010-03-04

  Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

  本文描述了含有这些化合物的药物组合物，这些化合物调节储存操作的钙（SOC）通道的活性。本文还描述了使用这种SOC通道调节剂的方法，单独或与其他化合物结合使用，用于治疗需要抑制SOC通道活性的疾病或症状。
• US7981925B2
  申请人：——

  公开号：US7981925B2

  公开（公告）日：2011-07-19
• US8372991B2
  申请人：——

  公开号：US8372991B2

  公开（公告）日：2013-02-12
• [EN] COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM<br/>[FR] COMPOSÉS MODULANT LE CALCIUM INTRACELLULAIRE
  申请人：CALCIMEDICA INC

  公开号：WO2010025295A2

  公开（公告）日：2010-03-04

  Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.