肾上腺素β-磺酸盐

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 肾上腺素β-磺酸盐
• 英文名称: (1R)-1-(3,4-dihydroxyphenyl)-2-(methylazaniumyl)ethanesulfonate
• 化学式: C9H13NO5S
• 分子量: 247.27
• InChiKey: TYYGQMPOZGEFQL-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.1
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  115
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Stable injectable pharmaceutical composition of epinephrine or salts thereof
  申请人：WOCKHARDT LIMITED

  公开号：US20150246009A1

  公开（公告）日：2015-09-03

  The present invention refers to a stabilized injectable pharmaceutical composition of epinephrine or salts thereof comprising sodium metabisulfite, wherein the ratio of the amount of epinephrine or salt thereof to sodium metabisulfite in the composition ranges from about 1:0.005 to about 1:1.5 by weight. It has been observed that stable injectable epinephrine compositions with excellent storage stability and substantially free of overages can be prepared using sodium metabisulfite in said ratios. Particularly, it was found that using sodium metabisulfite in said ratios controls levels of adrenaline sulfonate impurity in said pharmaceutical compositions.