3-Anilino-1-butanol | 17972-49-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-Anilino-1-butanol
• 英文别名: 3-Anilinobuten-1-ol；1-Butanol, 3-(phenylamino)-；3-anilinobutan-1-ol
• CAS: 17972-49-5
• 化学式: C₁₀H₁₅NO
• 分子量: 165.235
• InChiKey: UOIIVXRTQYVTBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-phenylaminobut-2-enoic acid ethyl ester 在 sodium 、 异丙醇 作用下， 以 四氢呋喃 为溶剂， 以55%的产率得到3-Anilino-1-butanol
  参考文献：
  名称：

  Chemo- and Diastereoselective Reduction of .beta.-Enamino Esters: A Convenient Synthesis of Both cis- and trans-.gamma.-Amino Alcohols and .beta.-Amino Esters

  摘要：

  Convenient procedures for the chemo- and diastereoselective reduction of beta-enamino esters 1 are described. Both cis- and trans-gamma-amino alcohols 2 or beta-amino esters 3 can be prepared by reduction of beta-enamino esters 1, readily available starting materials, with the use of inexpensive reagents Nali-PrOH or NaHbB(OAc)(3)/AcOH, respectively, and the appropriate reduction conditions. The mechanisms and diastereoselectivities for the reductions are discussed. The relative configurations and conformations of the diastereoisomeric gamma-amino alcohols 2 and beta-amino esters 3 obtained are established by H-1 and C-13 NMR study and unequivocally set by their cyclic derivatives tetrahydro-1,3-oxazines 4.

  DOI：

  10.1021/jo00097a039

文献信息

• NOVEL RUTHENIUM CARBONYL COMPLEX HAVING TRIDENTATE LIGAND, ITS PRODUCTION METHOD AND USE
  申请人：Kuriyama Wataru

  公开号：US20110237814A1

  公开（公告）日：2011-09-29

  The present invention relates to a ruthenium carbonyl complex that is represented by the following Formula (1): RuXY(CO)(L)  (1) (in the Formula (1), X and Y, which may be the same or different from each other, represent an anionic ligand and L represents a tridentate aminodiphosphine ligand which has two phosphino groups and a —NH— group), its production method, and a method for production of alcohols by hydrogenation-reduction of ketones, esters, and lactones using the complex as a catalyst. The ruthenium carbonyl complex of the invention has a high catalytic activity and it can be easily prepared and handled.

  本发明涉及一种由以下化学式（1）表示的钌羰基配合物： RuXY(CO)(L)  (1) （在化学式（1）中，X和Y可以相同也可以不同，代表一个阴离子配体，L代表一个三牙螯合胺二膦配体，具有两个膦基团和一个—NH—基团），以及其制备方法，以及利用该配合物作为催化剂通过酮、酯和内酯的加氢还原生产醇的方法。 本发明的钌羰基配合物具有高催化活性，且易于制备和处理。
• Aerobic oxidative coupling of alcohols and amines over Au–Pd/resin in water: Au/Pd molar ratios switch the reaction pathways to amides or imines
  作者：Leilei Zhang、Wentao Wang、Aiqin Wang、Yitao Cui、Xiaofeng Yang、Yanqiang Huang、Xiaoyan Liu、Wengang Liu、Jin-Young Son、Hiroshi Oji、Tao Zhang

  DOI：10.1039/c3gc41117f

  日期：——

  of the reaction pathways of aerobic oxidative coupling of alcohols and amines from amidation to imination was realized for the first time by tuning the Au/Pd ratios in ion-exchange resin supported Au–Pd alloy catalysts (Au–Pd/resin). Amides were obtained with high yields on Au6Pd/resin while imines were obtained over AuPd4/resin. Various alcohols and amines underwent oxidative coupling smoothly in

  轻度氧化有氧氧化反应途径的简便转换。 酒类 和 胺类 从酰胺化到 胺化 通过调节离子交换树脂负载的Au-Pd合金中的Au / Pd比率首次实现 催化剂 （Au–Pd /树脂）。 酰胺类在Au 6 Pd /树脂上以高收率获得亚胺通过AuPd 4 /树脂获得。各种各样的酒类 和 胺类 在氧化过程中顺利进行了氧化偶联 水以高至优异的产率提供所需的产品。对反应机理的进一步研究表明，金与钯的协同作用决定了铜的吸附强度。醛中间体，这反过来决定了反应途径。也就是说，在富金合金（例如Au 6 Pd）上被吸收醛 物种形成，随后进一步 氧化作用 屈服 酰胺类，而在富含Pd的合金（例如AuPd 4）上，则免费醛 产生，然后与 胺类 生产 亚胺。该发现可能为开发新的高效方法提供途径催化剂 用于绿色合成的特殊化学品。
• NOVEL RUTHENIUM CARBONYL COMPLEX HAVING A TRIDENTATE LIGAND AND MANUFACTURING METHOD AND USAGE THEREFOR
  申请人：Takasago International Corporation

  公开号：EP2492275A1

  公开（公告）日：2012-08-29

  The present invention relates to a ruthenium carbonyl complex that is represented by the following Formula (1):         RuXY(CO)(L)     (1) (in the Formula (1), X and Y, which may be the same or different from each other, represent an anionic ligand and L represents a tridentate aminodiphosphine ligand which has two phophino groups and a -NH- group), its production method, and a method for production of alcohols by hydrogenation-redcution of ketones, esters, and lactones using the complex as a catalyst. The ruthenium carbonyl complex of the invention has a high catalytic activity and it can be easily prepared and handled.

  本发明涉及一种由下式（1）表示的羰基钌络合物： RuXY(CO)(L) (1) 式（1）中，X 和 Y（可以相同或不同）代表阴离子配体，L 代表具有两个膦基和一个 -NH- 基团的三叉氨基二膦配体）及其生产方法，以及使用该络合物作为催化剂通过酮、酯和内酯的氢化-还原反应生产醇的方法。 本发明的羰基钌络合物具有很高的催化活性，而且易于制备和处理。
• Method for producing alcohols
  申请人：Takasago International Corporation

  公开号：EP1970360B1

  公开（公告）日：2016-08-31
• US5672760A
  申请人：——

  公开号：US5672760A

  公开（公告）日：1997-09-30