Methyl 4-(3-chloro-5-(methylcarbamoyl)pyridin-2-yl)-1-(1-(4-chlorobenzyl)piperidin-4-yl)piperazine-2-carboxylate | 1279723-78-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: Methyl 4-(3-chloro-5-(methylcarbamoyl)pyridin-2-yl)-1-(1-(4-chlorobenzyl)piperidin-4-yl)piperazine-2-carboxylate
• 英文别名: methyl 4-[3-chloro-5-(methylcarbamoyl)pyridin-2-yl]-1-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]piperazine-2-carboxylate
• CAS: 1279723-78-2
• 化学式: C₂₅H₃₁Cl₂N₅O₃
• 分子量: 520.459
• InChiKey: ZVQHEZKGRFHDCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  78
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  Methyl 4-(3-chloro-5-(methylcarbamoyl)pyridin-2-yl)-1-(1-(4-chlorobenzyl)piperidin-4-yl)piperazine-2-carboxylate 在 水 、 N,N-二异丙基乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 、 lithium hydroxide 作用下， 以 四氢呋喃 、 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 21.0h， 生成 4-(3-chloro-5-(methylcarbamoyl)pyridin-2-yl)-1-(1-(4-chlorobenzyl)piperidin-4-yl)-N-methylpiperazine-2-carboxamide
  参考文献：
  名称：

  II. SAR studies of pyridyl–piperazinyl-piperidine derivatives as CXCR3 chemokine antagonists

  摘要：

  The structure-human CXCR3 binding affinity relationship of a series of pyridyl-piperazinyl-piperidine derivatives was explored. The optimization campaign highlighted the pronounced effect of 2'-piperazine substitution on CXCR3 receptor affinity. Analog 18j, harboring a 2'(S)-ethylpiperazine moiety, exhibited a human CXCR3 IC(50) of 0.2 nM. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.12.114

文献信息

• II. SAR studies of pyridyl–piperazinyl-piperidine derivatives as CXCR3 chemokine antagonists
  作者：Yuefei Shao、Gopinadhan N. Anilkumar、Carolyn DiIanni Carroll、Guizhen Dong、James W. Hall、Doug W. Hobbs、Yueheng Jiang、Chung-Her Jenh、Seong Heon Kim、Joseph A. Kozlowski、Brian F. McGuinness、Stuart B. Rosenblum、Inna Schulman、Neng-Yang Shih、Youheng Shu、Michael K.C. Wong、Wensheng Yu、Lisa Guise Zawacki、Qingbei Zeng

  DOI：10.1016/j.bmcl.2010.12.114

  日期：2011.3

  The structure-human CXCR3 binding affinity relationship of a series of pyridyl-piperazinyl-piperidine derivatives was explored. The optimization campaign highlighted the pronounced effect of 2'-piperazine substitution on CXCR3 receptor affinity. Analog 18j, harboring a 2'(S)-ethylpiperazine moiety, exhibited a human CXCR3 IC(50) of 0.2 nM. (C) 2011 Elsevier Ltd. All rights reserved.