6-(2-(piperidin-1-yl))ethyl-6H-indolo[2,3-b]quinoxaline | 59184-60-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6-(2-(piperidin-1-yl))ethyl-6H-indolo[2,3-b]quinoxaline
• 英文别名: 6-(2-Piperidinoethyl)-6H-indolo[2,3-B]quinoxaline；6-(2-piperidin-1-ylethyl)indolo[3,2-b]quinoxaline
• CAS: 59184-60-0
• 化学式: C₂₁H₂₂N₄
• 分子量: 330.432
• InChiKey: HFWVWBPZEAYHMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  34
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  哌啶 、 6-(2-bromoethyl)-6H-indolo[2,3-b]quinoxaline 以 苯 为溶剂， 以87%的产率得到6-(2-(piperidin-1-yl))ethyl-6H-indolo[2,3-b]quinoxaline
  参考文献：
  名称：

  Synthesis, cytotoxicity, antiviral activity and interferon inducing ability of 6-(2-aminoethyl)-6H-indolo[2,3-b]quinoxalines

  摘要：

  New 6-(2-aminoethyl)-6H-indolo[2,3-b]quinoxalines were synthesized with high yields using bromoethylisatin and 6-(2-bromoethyl)-6H-indolo[2,3-b]quinoxaline as intermediates. These compounds were screened for the cytotoxicity, antiviral activity and interferon inducing ability. it was shown, that tested 6-(2-aminoethyl)-6H-indolo[2,3-b]quinoxalines are low toxic potent interferon inducers and antivirals. Morpholine and 4-methyl-piperidine derivatives appeared as the most active antivirals and the least cytotoxic in the investigated series. (C) 2009 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2009.12.014

文献信息

• KNOTZ F.; WENDELIN W., SCI. PHARM. <SCPH-A4>, 1975, 43, NO 4, 249-260
  作者：KNOTZ F.、 WENDELIN W.

  DOI：——

  日期：——
• INHIBITION OF NF-KB
  申请人：Gudkov Andrei V.

  公开号：US20090099191A1

  公开（公告）日：2009-04-16

  The present invention is generally related to the modulation of cell growth or apoptosis. Compositions for modulating cell growth or apoptosis, methods of use thereof, and methods of identification thereof are described.
• Synthesis, cytotoxicity, antiviral activity and interferon inducing ability of 6-(2-aminoethyl)-6H-indolo[2,3-b]quinoxalines
  作者：Marina O. Shibinskaya、Sergey A. Lyakhov、Alexander V. Mazepa、Sergey A. Andronati、Alexander V. Turov、Nadezhda M. Zholobak、Nikolay Ya. Spivak

  DOI：10.1016/j.ejmech.2009.12.014

  日期：2010.3

  New 6-(2-aminoethyl)-6H-indolo[2,3-b]quinoxalines were synthesized with high yields using bromoethylisatin and 6-(2-bromoethyl)-6H-indolo[2,3-b]quinoxaline as intermediates. These compounds were screened for the cytotoxicity, antiviral activity and interferon inducing ability. it was shown, that tested 6-(2-aminoethyl)-6H-indolo[2,3-b]quinoxalines are low toxic potent interferon inducers and antivirals. Morpholine and 4-methyl-piperidine derivatives appeared as the most active antivirals and the least cytotoxic in the investigated series. (C) 2009 Elsevier Masson SAS. All rights reserved.