6-(2-(4-methylpiperidin-1-yl))ethyl-6H-indolo[2,3-b]quinoxaline | 1216689-55-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6-(2-(4-methylpiperidin-1-yl))ethyl-6H-indolo[2,3-b]quinoxaline
• 英文别名: 6-[2-(4-Methylpiperidin-1-yl)ethyl]indolo[3,2-b]quinoxaline
• CAS: 1216689-55-2
• 化学式: C₂₂H₂₄N₄
• 分子量: 344.459
• InChiKey: HXMLCNLSHQJYPL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  34
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-甲基哌啶 、 6-(2-bromoethyl)-6H-indolo[2,3-b]quinoxaline 以 苯 为溶剂， 以80%的产率得到6-(2-(4-methylpiperidin-1-yl))ethyl-6H-indolo[2,3-b]quinoxaline
  参考文献：
  名称：

  Synthesis, cytotoxicity, antiviral activity and interferon inducing ability of 6-(2-aminoethyl)-6H-indolo[2,3-b]quinoxalines

  摘要：

  New 6-(2-aminoethyl)-6H-indolo[2,3-b]quinoxalines were synthesized with high yields using bromoethylisatin and 6-(2-bromoethyl)-6H-indolo[2,3-b]quinoxaline as intermediates. These compounds were screened for the cytotoxicity, antiviral activity and interferon inducing ability. it was shown, that tested 6-(2-aminoethyl)-6H-indolo[2,3-b]quinoxalines are low toxic potent interferon inducers and antivirals. Morpholine and 4-methyl-piperidine derivatives appeared as the most active antivirals and the least cytotoxic in the investigated series. (C) 2009 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2009.12.014

文献信息

• Synthesis, cytotoxicity, antiviral activity and interferon inducing ability of 6-(2-aminoethyl)-6H-indolo[2,3-b]quinoxalines
  作者：Marina O. Shibinskaya、Sergey A. Lyakhov、Alexander V. Mazepa、Sergey A. Andronati、Alexander V. Turov、Nadezhda M. Zholobak、Nikolay Ya. Spivak

  DOI：10.1016/j.ejmech.2009.12.014

  日期：2010.3

  New 6-(2-aminoethyl)-6H-indolo[2,3-b]quinoxalines were synthesized with high yields using bromoethylisatin and 6-(2-bromoethyl)-6H-indolo[2,3-b]quinoxaline as intermediates. These compounds were screened for the cytotoxicity, antiviral activity and interferon inducing ability. it was shown, that tested 6-(2-aminoethyl)-6H-indolo[2,3-b]quinoxalines are low toxic potent interferon inducers and antivirals. Morpholine and 4-methyl-piperidine derivatives appeared as the most active antivirals and the least cytotoxic in the investigated series. (C) 2009 Elsevier Masson SAS. All rights reserved.