6-(Methylthio)-2H-benzo[b][1,4]thiazin-3(4H)-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 6-(Methylthio)-2H-benzo[b][1,4]thiazin-3(4H)-one
• 英文别名: 6-methylsulfanyl-4H-1,4-benzothiazin-3-one
• 化学式: C₉H₉NOS₂
• 分子量: 211.3
• InChiKey: PIEYDXRGRMYIDY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  79.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Substituted oxazolidines as anti-bacterial agents
  申请人：BUGWORKS RESEARCH, INC.

  公开号：US10711011B2

  公开（公告）日：2020-07-14

  The present disclosure relates to compounds of Formula I, its stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms thereof and pharmaceutical compositions containing them as the active ingredient which can be used as medicaments. The aforementioned substances can also be used in the manufacture of medicaments for treatment, prevention or suppression of diseases, and conditions mediated by microbes. The present disclosure also relates to the synthesis and characterization of aforementioned substances.

  本公开涉及可用作药物的式 I 化合物、其立体异构体、药学上可接受的盐、络合物、水合物、溶 液物、同系物、多晶型物、外消旋混合物、其光学活性形式以及含有它们作为活性成分的药物 组合物。上述物质还可用于制造治疗、预防或抑制由微生物介导的疾病和病症的药物。本公开还涉及上述物质的合成和表征。
• HETEROCYCLIC COMPOUNDS USEFUL AS ANTI-BACTERIAL AGENTS AND METHOD FOR PRODUCTION
  申请人：BUGWORKS RESEARCH, INC.

  公开号：US20190292199A1

  公开（公告）日：2019-09-26

  The present disclosure relates to compounds of Formula I, its stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms thereof and pharmaceutical compositions containing them as the active ingredient which can be used as medicaments. The aforementioned substances can also be used in the manufacture of medicaments for treatment, prevention or suppression of diseases, and conditions mediated by microbes. The present disclosure also relates to the synthesis and characterization of aforementioned substances.