(5Z)-3-[4-Oxo-4-(10H-phenothiazin-10-YL)butyl]-2-sulfanylidene-5-[(thiophen-2-YL)methylidene]-1,3-thiazolidin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: (5Z)-3-[4-Oxo-4-(10H-phenothiazin-10-YL)butyl]-2-sulfanylidene-5-[(thiophen-2-YL)methylidene]-1,3-thiazolidin-4-one
• 英文别名: (5Z)-3-(4-oxo-4-phenothiazin-10-ylbutyl)-2-sulfanylidene-5-(thiophen-2-ylmethylidene)-1,3-thiazolidin-4-one
• 化学式: C₂₄H₁₈N₂O₂S₄
• 分子量: 494.7
• InChiKey: NAORDQKTRIGKPV-QNGOZBTKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  152
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Oxazole and thiazole compounds as beta-catenin modulators and uses thereof
  申请人：Dasgupta Ramanuj

  公开号：US20090227624A1

  公开（公告）日：2009-09-10

  A series of oxazole and thiazole compounds are shown herein to be small molecule inhibitors of the Wnt pathway that specifically target the activity of the stabilized pool of β-cat oxazole and thiazole compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, cancer, and others.
• OXAZOLE AND THIAZOLE COMPOUNDS AS BETA-CATENIN MODULATORS AND USES THEREOF
  申请人：Dasgupta Ramanuj

  公开号：US20130109675A1

  公开（公告）日：2013-05-02

  A series of oxazole and thiazole compounds are shown herein to be small molecule inhibitors of the Wnt pathway that specifically target the activity of the stabilized pool of β-cat oxazole and thiazole compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, cancer, and others.
• US8252823B2
  申请人：——

  公开号：US8252823B2

  公开（公告）日：2012-08-28
• US9433611B2
  申请人：——

  公开号：US9433611B2

  公开（公告）日：2016-09-06