1-(Diethylamino)-3-(1,1-dimethylethoxy)-2-propanol | 136987-55-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-(Diethylamino)-3-(1,1-dimethylethoxy)-2-propanol
• 英文别名: 1-(diethylamino)-3-[(2-methylpropan-2-yl)oxy]propan-2-ol
• CAS: 136987-55-8
• 化学式: C₁₁H₂₅NO₂
• 分子量: 203.325
• InChiKey: GLDGBVXTRSSESY-UHFFFAOYSA-N

物化性质

• 沸点：
  273.8±25.0 °C(Predicted)
• 密度：
  0.917±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  叔丁基缩水甘油醚 、 二乙胺 以 水 为溶剂， 反应 10.0h， 以67%的产率得到1-(Diethylamino)-3-(1,1-dimethylethoxy)-2-propanol
  参考文献：
  名称：

  Synthesis and uterostimulating activity of derivatives of 1-dialkylamino-3-alkoxy-2-propanol

  摘要：

  DOI：

  10.1007/bf00772007

文献信息

• Substituted quinazoline compounds and methods of use
  申请人：ARAXES PHARMA LLC

  公开号：US10822312B2

  公开（公告）日：2020-11-03

  The present disclosure provides inhibitors of Ras protein of Formula (I-A): Also disclosed are methods to modulate the activity of Ras protein and methods of treatment of disorders mediated by Ras protein with compounds of Formula (I-A).

  本公开提供了式 (I-A) 的 Ras 蛋白抑制剂： 还公开了用式（I-A）化合物调节 Ras 蛋白活性的方法和治疗由 Ras 蛋白介导的疾病的方法。
• Aluminium triflate: an efficient recyclable Lewis acid catalyst for the aminolysis of epoxides
  作者：D. Bradley G. Williams、Michelle Lawton

  DOI：10.1016/j.tetlet.2006.07.036

  日期：2006.9

  Epoxides are powerful starting materials for a range of useful materials and can be converted into, amongst others, amino alcohols. In this work, a range of epoxides was ring-opened using various alkyl- and arylamines under the action of aluminium triflate as a catalyst. This catalyst was found to be highly active, producing the desired amino alcohol products in high yields with low catalyst loadings. Additionally, it was shown that the aluminium triflate catalyst is recyclable by simple extraction into water and may be re-used several times. (c) 2006 Elsevier Ltd. All rights reserved.
• SUBSTITUTED QUINAZOLINE COMPOUNDS AND METHODS OF USE
  申请人：ARAXES PHARMA LLC

  公开号：US20190127336A1

  公开（公告）日：2019-05-02

  The present disclosure provides inhibitors of Ras protein. Also disclosed are methods to modulate the activity of Ras protein and methods of treatment of disorders mediated by Ras protein.