胆碱硬脂酸酯 | 23464-76-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 胆碱硬脂酸酯
• 中文别名: 吡咯并[1,2-a]吡嗪-1(2H)-酮,六氢-4-甲基-,(4S-cis)-(9CI)
• 英文名称: Choline stearate
• 英文别名: trimethyl(2-octadecanoyloxyethyl)azanium
• CAS: 23464-76-8
• 化学式: C23H48NO2+
• 分子量: 370.6
• InChiKey: SGFBLYBOTWZDDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.6
• 重原子数：
  26
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2923900090

文献信息

• Uridine administration improves phosphatide synthesis, synaptic transmission and cogntive function
  申请人：Wurtman J. Richard

  公开号：US20050187182A1

  公开（公告）日：2005-08-25

  The present invention provides methods of improving a cognitive function or a neurological function, treating or ameliorating a decline in a cognitive function or a neurological function, increasing cytidine levels, or treating a neurological disorder in a subject, comprising administering a uridine, a uridine precursor, or a derivative or metabolite thereof to the subject. The invention also provides methods of improving neural function, comprising contacting the neuron with a uridine, a uridine precursor, or a derivative or metabolite thereof.

  本发明提供了改善认知功能或神经功能、治疗或改善认知功能或神经功能下降、增加胞苷水平或治疗受试者神经系统疾病的方法，包括向受试者给予脲苷、脲苷前体或其衍生物或代谢物。本发明还提供了改善神经功能的方法，包括使用脲苷、脲苷前体或其衍生物或代谢物与神经元接触。
• Compositions containing uridine and choline, and methods utilizing same
  申请人：Wurtman Dick

  公开号：US20060069061A1

  公开（公告）日：2006-03-30

  The present invention is directed to methods of improving cognitive and neurological functions and increasing synthesis and release of neurotransmitters and membrane synthesis by neural cells and brain cells, comprising administering a composition comprising a uridine and a choline.

  本发明涉及一种改善认知和神经功能，增加神经细胞和脑细胞合成和释放神经递质和膜合成的方法，包括给予含有尿嘧啶和胆碱的组合物。
• Methods and compositions for ameliorating or inhibiting decline in memory or intelligence or improving same
  申请人：Wurtman Richard

  公开号：US20060241077A1

  公开（公告）日：2006-10-26

  The present invention is directed to methods of ameliorating hippocampal dysfunction and improving or inhibiting decline in intelligence or cognitive or hippocampal-dependent memory of a subject and of increasing synthesis and release of neurotransmitters, neurite outgrowth, and levels of neurofilament proteins in the brain and CNS of a subject, comprising administering to the subject a uridine, an acyl derivative thereof, a uridine phosphate, uracil, or a salt thereof.

  本发明涉及改善海马功能障碍并改善或抑制受试者的智力或认知或依赖于海马的记忆力下降的方法，以及增加神经递质的合成和释放，神经元突起生长和神经丝蛋白水平的方法在受试者的大脑和中枢神经系统中，包括向受试者投与尿嘧啶、其酰基衍生物、尿嘧啶磷酸盐、尿嘧啶或其盐。
• METHODS AND COMPOSITIONS FOR AMELIORATING OR INHIBITING DECLINE IN MEMORY OR INTELLIGENCE OR IMPROVING SAME
  申请人：Wurtman Dick

  公开号：US20090105189A1

  公开（公告）日：2009-04-23

  The present invention is directed to methods and compositions for treating and ameliorating AAMI, hippocampal dysfunction, memory disorders, and brain damage, comprising a composition comprising uridine, an acyl derivative thereof, or a uridine phosphate.

  本发明涉及用于治疗和改善AAMI、海马功能障碍、记忆障碍和脑损伤的方法和组合物，包括一种含有尿嘧啶、其酰基衍生物或尿嘧啶磷酸盐的组合物。
• Use of a (1>3)-Beta-D-Glucan as an Emulsion Stabiliser
  申请人：Lommerts Bert Jan

  公开号：US20110168055A1

  公开（公告）日：2011-07-14

  The present invention relates to the use of a (1→3)-β-D-glucan as an emulsion stabiliser. The present invention further relates to emulsions comprising a (1→3)-β-D-glucan in an amount of 0.01 to 10 wt. %, based on the total weight of the emulsion. The present invention also relates to bitumen binder compositions comprising a (1→3)-β-D-glucan in an amount of 0.005 to less than 0.1 wt. %, based on the total weight of the bitumen binder composition. The present invention further relates to emulsions comprising a novel biodegradable emulsifying agent, in particular in combination with a (1→3)-β-D-glucan.

  本发明涉及使用(1→3)-β-D-葡聚糖作为乳化稳定剂。本发明还涉及含有(1→3)-β-D-葡聚糖的乳液，其重量百分比为0.01至10％，基于乳液的总重量。本发明还涉及含有(1→3)-β-D-葡聚糖的沥青粘合剂组合物，其重量百分比为0.005至少于0.1％，基于沥青粘合剂组合物的总重量。本发明还涉及含有新型可生物降解乳化剂的乳液，特别是与(1→3)-β-D-葡聚糖结合的乳化剂。