3',6'-Dinitro-1,2-naphthoylen-benzimidazol | 23986-31-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3',6'-Dinitro-1,2-naphthoylen-benzimidazol
• 英文别名: 2,5-dinitro-benzo[de]benzo[4,5]imidazo[2,1-a]isoquinolin-7-one；2,5-dinitro-benzo[de]benz[4,5]imidazo[2,1-a]isoquinolin-7-one；2,5-Dinitro-benzo[de]benz[4,5]imidazo[2,1-a]isochinolin-7-on；2,5-dinitro-7H-benzimidazo[2,1-a]benzo[de]isoquinolin-7-one；14,18-dinitro-3,10-diazapentacyclo[10.7.1.02,10.04,9.016,20]icosa-1(20),2,4,6,8,12,14,16,18-nonaen-11-one
• CAS: 23986-31-4
• 化学式: C₁₈H₈N₄O₅
• mdl: MFCD00358621
• 分子量: 360.285
• InChiKey: RUNCFXWZYYBERT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  27
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  127
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3,6-dinitro-1,8-naphthalic anhydride 、 邻苯二胺 在 溶剂黄146 作用下， 生成 3',6'-Dinitro-1,2-naphthoylen-benzimidazol
  参考文献：
  名称：

  368. ena和and

  摘要：

  DOI：

  10.1039/jr9370001761

文献信息

• Methods and compositions for treating beta-thalassemia and sickle cell disease
  申请人：Academia Sinica

  公开号：EP2678339B1

  公开（公告）日：2016-07-13
• METHODS AND COMPOSITIONS FOR TREATING BETA-THALASSEMIA AND SICKLE CELL DISEASE
  申请人：Shen Che-Kun James

  公开号：US20140088133A1

  公开（公告）日：2014-03-27

  The present invention provides compounds (such as compounds of formula I-a) that induce γ globin expression and pharmaceutical compositions thereof. Such compounds may have beneficial therapeutic effects. Compounds and compositions described herein may be used to treat hemoglobinopathies such as β-thalassemia and sickle cell anemia. (I-a)
• US8822491B2
  申请人：——

  公开号：US8822491B2

  公开（公告）日：2014-09-02
• [EN] METHODS AND COMPOSITIONS FOR TREATING ß-THALASSEMIA AND SICKLE CELL DISEASE<br/>[FR] MÉTHODES ET COMPOSITIONS POUR LE TRAITEMENT DE LA ?-THALASSÉMIE ET DE LA DRÉPANOCYTOSE
  申请人：ACADEMIA SINICA

  公开号：WO2012112232A1

  公开（公告）日：2012-08-23

  The present invention provides compounds (such as compounds of formula I-a) that induce γ globin expression and pharmaceutical compositions thereof. Such compounds may have beneficial therapeutic effects. Compounds and compositions described herein may be used to treat hemoglobinopathies such as β-thalassemia and sickle cell anemia. (I-a)
• 368. Acenaphthenone and acenaphthenequinone
  作者：H. Gordon Rule、Samuel B. Thompson

  DOI：10.1039/jr9370001761

  日期：——