(R)-2,6-Dimethyl-heptylamine | 89999-57-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (R)-2,6-Dimethyl-heptylamine
• 英文别名: (2R)-2,6-dimethylheptan-1-amine
• CAS: 89999-57-5
• 化学式: C₉H₂₁N
• 分子量: 143.272
• InChiKey: HWDRGAFTIGABCW-SECBINFHSA-N

物化性质

• 沸点：
  74 °C(Press: 15 Torr)
• 密度：
  0.789±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  6-chloro-1H-indole-2,3-dicarboxylic acid 2-ethyl ester 、 (R)-2,6-Dimethyl-heptylamine 在 1-羟基苯并三唑 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 4.5h， 以82%的产率得到ethyl (R)-6-chloro-3-((2,6-dimethylheptyl)carbamoyl)-1H-indole-2-carboxylate
  参考文献：
  名称：

  Novel 15-Lipoxygenase-1 Inhibitor Protects Macrophages from Lipopolysaccharide-Induced Cytotoxicity

  摘要：

  Various mechanisms for regulated cell death include the formation of oxidative mediators such as lipid peroxides and nitric oxide (NO). In this respect, 15-lipoxygenase-1 (15-LOX-1) is a key enzyme that catalyzes the formation of lipid peroxides. The actions of these peroxides are interconnected with nuclear factor-?B signaling and NO production. Inhibition of 15-LOX-1 holds promise to interfere with regulated cell death in inflammatory conditions. In this study, a novel potent 15-LOX-1 inhibitor, 9c (i472), was developed and structure-activity relationships were explored. In vitro, this inhibitor protected cells from lipopolysaccharide-induced cell death, inhibiting NO formation and lipid peroxidation. Thus, we provide a novel 15-LOX-1 inhibitor that inhibits cellular NO production and lipid peroxidation, which set the stage for further exploration of these mechanisms.

  DOI：

  10.1021/acs.jmedchem.9b00212
• 作为产物：
  描述：

  [(S)-2,6-Dimethyl-hept-(E)-ylidene]-((S)-2-methoxymethyl-pyrrolidin-1-yl)-amine 在 镍 氢气 作用下， 以 甲醇 、 乙醚 为溶剂， 40.0 ℃ 、380.0 kPa 条件下， 反应 36.0h， 生成 (R)-2,6-Dimethyl-heptylamine
  参考文献：
  名称：

  Enders, Dieter; Schubert, Heinrich, Angewandte Chemie, 1984, vol. 96, # 5, p. 368 - 369

  摘要：

  DOI：

文献信息

• Novel 15-Lipoxygenase-1 Inhibitor Protects Macrophages from Lipopolysaccharide-Induced Cytotoxicity
  作者：Hao Guo、Iris C. Verhoek、Gerian G. H. Prins、Ramon van der Vlag、Petra E. van der Wouden、Ronald van Merkerk、Wim J. Quax、Peter Olinga、Anna K. H. Hirsch、Frank J. Dekker

  DOI：10.1021/acs.jmedchem.9b00212

  日期：2019.5.9

  Various mechanisms for regulated cell death include the formation of oxidative mediators such as lipid peroxides and nitric oxide (NO). In this respect, 15-lipoxygenase-1 (15-LOX-1) is a key enzyme that catalyzes the formation of lipid peroxides. The actions of these peroxides are interconnected with nuclear factor-?B signaling and NO production. Inhibition of 15-LOX-1 holds promise to interfere with regulated cell death in inflammatory conditions. In this study, a novel potent 15-LOX-1 inhibitor, 9c (i472), was developed and structure-activity relationships were explored. In vitro, this inhibitor protected cells from lipopolysaccharide-induced cell death, inhibiting NO formation and lipid peroxidation. Thus, we provide a novel 15-LOX-1 inhibitor that inhibits cellular NO production and lipid peroxidation, which set the stage for further exploration of these mechanisms.
• Enders, Dieter; Schubert, Heinrich, Angewandte Chemie, 1984, vol. 96, # 5, p. 368 - 369
  作者：Enders, Dieter、Schubert, Heinrich

  DOI：——

  日期：——