1,4-bis-(1-anilinoethyl)benzene | 1047-77-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,4-bis-(1-anilinoethyl)benzene
• 英文别名: 1,4-Bis-(1-anilinoethyl) benzene；N-[1-[4-(1-anilinoethyl)phenyl]ethyl]aniline
• CAS: 1047-77-4
• 化学式: C₂₂H₂₄N₂
• 分子量: 316.446
• InChiKey: LESHUEYGKQTRAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-[4-(C-methyl-N-phenylcarbonimidoyl)phenyl]-N-phenylethanimine 在 三乙基硅烷 、 、 水 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以100%的产率得到1,4-bis-(1-anilinoethyl)benzene
  参考文献：
  名称：

  Room temperature tandem hydroamination and hydrosilation/protodesilation catalysis by a tricarbonylchromium-bound iridacycle

  摘要：

  一种与铬三羰基结合的铱环新显示出独特的催化性能，能够在温和的“一锅法”条件下，通过串联的氢胺化反应和氢硅化/质脱硅反应，将末端芳香炔烃转化为外消旋的N-苯基、1-芳基乙胺。

  DOI：

  10.1039/c2cc35520e

文献信息

• [EN] TRICYCLIC AMINO CONTAINING COMPOUNDS FOR TREATMENT OR PREVENTION OF SYMPTOMS ASSOCIATED WITH ENDOCRINE DYSFUNCTION<br/>[FR] COMPOSÉS CONTENANT DES ACIDES AMINÉS TRICYCLIQUES POUR LE TRAITEMENT OU LA PRÉVENTION DE SYMPTÔMES ASSOCIÉS À UN DYSFONCTIONNEMENT ENDOCRINIEN
  申请人：UNIV EMORY

  公开号：WO2013070660A1

  公开（公告）日：2013-05-16

  The disclosure provides methods of use of certain compounds that are useful for treating certain symptoms of endocrine disturbances, and in particular those associated with hot flashes.

  本公开提供了使用某些化合物治疗内分泌紊乱的某些症状的方法，特别是与潮热相关的症状的方法。
• Antioxidant for polyester fluids - alpha - methyl - n
  申请人：Uniroyal Chemical Company, Inc.

  公开号：US04962234A1

  公开（公告）日：1990-10-09

  An antioxidant for lubricating oils comprising an amine compound selected from substituted benzylamines or a substituted 1-amino-1,2,3,4-tetrahydro-naphthalene. The preferred anti-oxidants are N-(alpha -methyl -p -octylbenzyl) aniline, N-(alpha-methylbenzyl)- p -nonylaniline or 1-( p -dodecylanilino)-1,2,3,4-tetrahydronaphthalene.

  一种用于润滑油的抗氧化剂，包括从取代苯基胺或取代的1-氨基-1,2,3,4-四氢萘中选择的胺化合物。首选的抗氧化剂是N-(α-甲基-p-辛基苯基)苯胺，N-(α-甲基苄基)-p-壬基苯胺或1-(p-十二烷基苯胺基)-1,2,3,4-四氢萘。
• Amino compounds and use of amino compounds as antioxydant in lubricating oils
  申请人：UNIROYAL, INC.

  公开号：EP0022281A1

  公开（公告）日：1981-01-14

  An antioxidant for lubricating oils comprising an amine compound selected from substituted benzylamines or a substituted 1-amino-1,2,3,4- tetrahydro-naphthalene. The preferred antioxidants are N-(alpha -methyl -p -octylbenzyl) aniline, N-(alphamethylbenzyl)- p -nonylaniline or 1-( p -dodecylanilino)-1,2,3,4- tetrahydronaphthalene.

  一种用于润滑油的抗氧化剂，包含一种胺化合物，选自取代的苄胺或取代的 1-氨基-1,2,3,4-四氢萘。 优选的抗氧化剂为 N-（α-甲基-对-辛基苄基）苯胺、N-（α-甲基苄基）-对-壬基苯胺或 1-（对-十二烷基苯胺）-1,2,3,4-四氢萘。
• Tricyclic amino containing compounds for treatment or prevention of symptoms associated with endocrine dysfunction
  申请人：Emory University

  公开号：US10632120B2

  公开（公告）日：2020-04-28

  The disclosure provides methods of use of certain compounds that are useful for treating certain symptoms of endocrine disturbances, and in particular those associated with hot flashes.

  本公开提供了某些化合物的使用方法，这些化合物可用于治疗内分泌紊乱的某些症状，尤其是与潮热相关的症状。
• Discovery of Small Molecule CXCR4 Antagonists
  作者：Weiqiang Zhan、Zhongxing Liang、Aizhi Zhu、Serdar Kurtkaya、Hyunsuk Shim、James P. Snyder、Dennis C. Liotta

  DOI：10.1021/jm070679i

  日期：2007.11.1

  In light of a proposed molecular mechanism for the C-X-C chemokine receptor type 4 (CXCR4) antagonist 1 (AMD3100), a template with the general structure 2 was designed, and 15 was identified as a lead by means of an affinity binding assay against the ligand-mimicking CXCR4 antagonist 3 (TN14003). Following a structure-activity profile around 15, the design and synthesis of a series of novel small molecular CXCR4 antagonists led to the discovery of 32 (WZ811). The compound shows subnanomolar potency (EC50 = 0.3 nM) in an affinity binding assay. In addition, when subjected to in vitro functional evaluation, 32 efficiently inhibits CXCR4/stromal cell-derived factor-1 (SDF-1)-mediated modulation of cyclic adenosine monophophate (CAMP) levels (EC50 = 1.2 nM) and SDF-1 induced Matrigel invasion (EC50 = 5.2 nM). Molecular field topology analysis (MFTA), a 2D quantitative structure-activity relationship (QSAR) approach based on local molecular properties (Van der Waals radii (VdW), atomic charges, and local lipophilicity), applied to the 32 series suggests structural modifications to improve potency.