4-(methylthio)-6-(2-naphthalenylsulfonyl)-2-quinazolinamine | 109890-46-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-(methylthio)-6-(2-naphthalenylsulfonyl)-2-quinazolinamine
• 英文别名: 4-[Methylthio]-6-[[2-naphthalenyl]sulfonyl]-2-quinazolinamine；4-methylsulfanyl-6-naphthalen-2-ylsulfonylquinazolin-2-amine
• CAS: 109890-46-2
• 化学式: C₁₉H₁₅N₃O₂S₂
• 分子量: 381.479
• InChiKey: BRSUHJMXDGPNBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  120
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-(methylthio)-6-(2-naphthalenylsulfonyl)-2-quinazolinamine 在 肼 作用下， 以 乙醇 为溶剂， 反应 25.5h， 以32%的产率得到4-hydrazino-6-(2-naphthalenylsulfonyl)-2-quinazolinamine
  参考文献：
  名称：

  Antimalarial drugs. 63. Synthesis and antimalarial and antitumor effects of 2-amino-4-(hydrazino and hydroxyamino)-6-[(aryl)thio]quinazolines

  摘要：

  A variety of analogues of 2,4-diamino-6-[(aryl)thio]quinazolines with known antimalarial properties were prepared wherein the 4-amino group was replaced by hydrazino and hydroxyamino moieties. Such changes were found to reduce markedly the antimalarial and antitumor properties of this series.

  DOI：

  10.1021/jm00394a038
• 作为产物：
  描述：

  2,4-diamino-6-(naphth-2-ylsulfonyl)quinazoline 在 盐酸 、 tetraphosphorus decasulfide 作用下， 以 吡啶 、 二乙二醇二甲醚 、 N,N-二甲基甲酰胺 为溶剂， 反应 72.0h， 生成 4-(methylthio)-6-(2-naphthalenylsulfonyl)-2-quinazolinamine
  参考文献：
  名称：

  Antimalarial drugs. 63. Synthesis and antimalarial and antitumor effects of 2-amino-4-(hydrazino and hydroxyamino)-6-[(aryl)thio]quinazolines

  摘要：

  A variety of analogues of 2,4-diamino-6-[(aryl)thio]quinazolines with known antimalarial properties were prepared wherein the 4-amino group was replaced by hydrazino and hydroxyamino moieties. Such changes were found to reduce markedly the antimalarial and antitumor properties of this series.

  DOI：

  10.1021/jm00394a038

文献信息

• Antimalarial drugs. 63. Synthesis and antimalarial and antitumor effects of 2-amino-4-(hydrazino and hydroxyamino)-6-[(aryl)thio]quinazolines
  作者：Leslie M. Werbel、Margaret J. Degnan

  DOI：10.1021/jm00394a038

  日期：1987.11

  A variety of analogues of 2,4-diamino-6-[(aryl)thio]quinazolines with known antimalarial properties were prepared wherein the 4-amino group was replaced by hydrazino and hydroxyamino moieties. Such changes were found to reduce markedly the antimalarial and antitumor properties of this series.