3-(3-morpholin-4-yl-propyl)-1H-quinazoline-2,4-dione | 4266-54-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-(3-morpholin-4-yl-propyl)-1H-quinazoline-2,4-dione
• 英文别名: 2-hydroxy-3-[3-(morpholin-4-yl)propyl]quinazolin-4(3H)-one；3-(3-morpholin-4-ylpropyl)-1H-quinazoline-2,4-dione
• CAS: 4266-54-0
• 化学式: C₁₅H₁₉N₃O₃
• mdl: MFCD03036642
• 分子量: 289.334
• InChiKey: FBUHJSLTQFPHBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  61.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-(3-氨丙基)吗啉 、 alkaline earth salt of/the/ methylsulfuric acid 在 异丁酰胺 、 potassium carbonate 作用下， 生成 3-(3-morpholin-4-yl-propyl)-1H-quinazoline-2,4-dione
  参考文献：
  名称：

  A practical solid phase synthesis of quinazoline-2,4-diones

  摘要：

  We describe a practical solid phase synthesis of quinazoline-2,4-diones using a short-chain, high loading capacity, polyethyleneglycol polystyrene copolymer ("PEG(4)-PS" resin). The highlights of this synthesis include efficient acyl azide formation on the solid phase, Curtius rearrangement, and cyclocleavage with K2CO3 followed by simple product isolation. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)01595-0

文献信息

• A practical solid phase synthesis of quinazoline-2,4-diones
  作者：Hui Shao、Marcus Colucci、Shaojing Tong、Hesheng Zhang、Arlindo L. Castelhano

  DOI：10.1016/s0040-4039(98)01595-0

  日期：1998.10

  We describe a practical solid phase synthesis of quinazoline-2,4-diones using a short-chain, high loading capacity, polyethyleneglycol polystyrene copolymer ("PEG(4)-PS" resin). The highlights of this synthesis include efficient acyl azide formation on the solid phase, Curtius rearrangement, and cyclocleavage with K2CO3 followed by simple product isolation. (C) 1998 Elsevier Science Ltd. All rights reserved.