N-(5-chloro-2-methoxyphenyl)-N'-(1-naphthyl)urea | 196868-72-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-(5-chloro-2-methoxyphenyl)-N'-(1-naphthyl)urea
• 英文别名: 1-(5-chloro-2-methoxyphenyl)-3-naphthalen-1-ylurea
• CAS: 196868-72-1
• 化学式: C₁₈H₁₅ClN₂O₂
• 分子量: 326.782
• InChiKey: NKXOLBLICDLSNE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  50.4
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  5-氯-2-甲氧基苯基异氰酸酯 、 1-萘胺 以 二甲基亚砜 为溶剂， 生成 N-(5-chloro-2-methoxyphenyl)-N'-(1-naphthyl)urea
  参考文献：
  名称：

  Evaluation of Diarylureas for Activity Against Plasmodium falciparum

  摘要：

  A library of diarylurea insulin-like growth factor 1 receptor inhibitors was screened for activity against chloroquine-sensitive (3D7) and chloroquine-resistant (K1) strains of Plasmodium falciparum. The 4-aminoquinaldine-derived diarylureas displayed promising antimalarial potency. Further exploration of the B ring of 4-aminoquinaldinyl ureas allowed identification of several quinaldin-4-yl ureas 4{13, 39} and 4{13, 58) sufficiently potent against both 3D7 and K1 strains to qualify as bone fide leads.

  DOI：

  10.1021/ml100083c

文献信息

• Evaluation of Diarylureas for Activity Against <i>Plasmodium falciparum</i>
  作者：Yiqun Zhang、Marc Anderson、Jennifer L. Weisman、Min Lu、Cindy J. Choy、Vincent A. Boyd、Jeanine Price、Martina Sigal、Julie Clark、Michele Connelly、Fangyi Zhu、W. Armand Guiguemde、Cynthia Jeffries、Lei Yang、Andrew Lemoff、Ally P. Liou、Thomas R. Webb、Joseph L. DeRisi、R. Kiplin Guy

  DOI：10.1021/ml100083c

  日期：2010.12.9

  A library of diarylurea insulin-like growth factor 1 receptor inhibitors was screened for activity against chloroquine-sensitive (3D7) and chloroquine-resistant (K1) strains of Plasmodium falciparum. The 4-aminoquinaldine-derived diarylureas displayed promising antimalarial potency. Further exploration of the B ring of 4-aminoquinaldinyl ureas allowed identification of several quinaldin-4-yl ureas 413, 39} and 413, 58) sufficiently potent against both 3D7 and K1 strains to qualify as bone fide leads.