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1,2-dihydro-1-benzylisoquinoline | 112119-93-4

中文名称
——
中文别名
——
英文名称
1,2-dihydro-1-benzylisoquinoline
英文别名
1-benzyl-1,2-dihydro-isoquinoline;1-Benzyl-1,2-dihydro-isochinolin;Dihydro-1-benzylisoquinoline;1-benzyl-1,2-dihydroisoquinoline
1,2-dihydro-1-benzylisoquinoline化学式
CAS
112119-93-4
化学式
C16H15N
mdl
——
分子量
221.302
InChiKey
YQLXLJUMGHFDMA-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    4
  • 重原子数:
    17
  • 可旋转键数:
    2
  • 环数:
    3.0
  • sp3杂化的碳原子比例:
    0.12
  • 拓扑面积:
    12
  • 氢给体数:
    1
  • 氢受体数:
    1

反应信息

  • 作为产物:
    描述:
    1-苄基异喹啉 以2%的产率得到
    参考文献:
    名称:
    R. , ALARKON XORXE;SOLDATOVA, S. A.;SOLDATENKOV, A. T.;RYASHENTSEVA, M. A+, IZV. AN CCCP. CEP. XIM.,(1991) N, S. 1413-1416
    摘要:
    DOI:
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文献信息

  • Hydrogenation of compounds containing an indolizine moiety and of 1-benzylisoquinoline over rhenium heptasulfide
    作者:R. Alarkon Khorkhe、S. A. Soldatova、A. T. Soldatenkov、M. A. Ryashentseva、N. S. Prostakov
    DOI:10.1007/bf00961308
    日期:1991.6
    It was shown by hydrogenation of 2,8-diphenylindolizine, benzo[2,3]indolizine, dibenzo[2,3;5,6]indolizine, dibenzo[2,3;7,8]indolizine, 1-benzylisoquinoline, and 2,3-dimethyl-6-ethyl-4-(4-nitrophenyl)pyridine over Re2S7 (250-degrees-C, P(H-2) = 140 atm, 4 h) that the pyridine ring in benzoindolizines is hydrolyzed in preference to the pyrrole ring. Phenyl substituents at the indolizine do not prevent its complete reduction while alkyl substituents make reduction difficult. Annelation of the pyrrole and pyridine rings of indolizine lower the degree of its reduction; a nitro group is reduced to an amino group.
  • Bergamann; Rosenthal, Journal fur praktische Chemie (Leipzig 1954), 1932, vol. 135, p. 267,276
    作者:Bergamann、Rosenthal
    DOI:——
    日期:——
  • R. , ALARKON XORXE;SOLDATOVA, S. A.;SOLDATENKOV, A. T.;RYASHENTSEVA, M. A+, IZV. AN CCCP. CEP. XIM.,(1991) N, S. 1413-1416
    作者:R. , ALARKON XORXE、SOLDATOVA, S. A.、SOLDATENKOV, A. T.、RYASHENTSEVA, M. A+
    DOI:——
    日期:——
  • EP1613635A2
    申请人:——
    公开号:EP1613635A2
    公开(公告)日:2006-01-11
  • Solid phase synthesis of antitumoral compounds
    申请人:Alvarez Mercedes
    公开号:US20060287529A1
    公开(公告)日:2006-12-21
    Lamellarins are prepared using a solid phase synthesis. In a first aspect, the process includes a step as follows: Formula (I) where R 1 to R 15 are as defined, and X is halogen, provided that one of R 2 , R 3 or R 4 is immobilised to a resin. In a second aspect, the process includes a step as follows: Formula (II) where R 1 ′ to R 5 ′, R 11 ′ and R 13 ′ are as defined, X 1 and X 2 are halogen, M is a metal function and PG is an amino protecting group, provided that one of that R 2 ′, R 3 ′ or R 4 ′ is immobilised to a resin.
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