1-{4-[methyl(5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)-amino]phenyl}-3-[3-(trifluoromethyl)phenyl]urea | 1255948-58-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-{4-[methyl(5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)-amino]phenyl}-3-[3-(trifluoromethyl)phenyl]urea
• 英文别名: 1-[4-[methyl-(5-methylpyrrolo[3,2-d]pyrimidin-4-yl)amino]phenyl]-3-[3-(trifluoromethyl)phenyl]urea
• CAS: 1255948-58-3
• 化学式: C₂₂H₁₉F₃N₆O
• 分子量: 440.428
• InChiKey: MNSYGLMJOPPFTK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  75.1
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  N-methyl-N-(5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)-benzene-1,4-diamine 、 3-(三氟甲基)异氰酸苯酯 以 四氢呋喃 为溶剂， 反应 15.0h， 以80%的产率得到1-{4-[methyl(5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)-amino]phenyl}-3-[3-(trifluoromethyl)phenyl]urea
  参考文献：
  名称：

  Design, synthesis, and evaluation of 5-methyl-4-phenoxy-5H-pyrrolo[3,2-d]pyrimidine derivatives: Novel VEGFR2 kinase inhibitors binding to inactive kinase conformation

  摘要：

  We synthesized a series of pyrrolo[3,2-d] pyrimidine derivatives and evaluated their application as type-II inhibitors of vascular endothelial growth factor receptor 2 (VEGFR2) kinase. Incorporation of a diphenylurea moiety at the C4-position of the pyrrolo[3,2-d] pyrimidine core via an oxygen linker resulted in compounds that were potent inhibitors of VEGFR2 kinase. Of these derivatives, compound 20d showed the strongest inhibition of VEGF-stimulated proliferation of human umbilical vein endothelial cells (HUVEC). The co-crystal structure of 20d and VEGFR2 revealed that 20d binds to the inactive form of VEGFR2. Further studies indicated that 20d inhibited VEGFR2 kinase with slow dissociation kinetics and also inhibited PDGFR and Tie-2 kinases. Oral administration of the hydrochloride salt of 20d at 3 mg/kg/day showed potent inhibition of tumor growth in a DU145 human prostate cancer cell xenograft nude mouse model. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.08.017

文献信息

• Design, synthesis, and evaluation of 5-methyl-4-phenoxy-5H-pyrrolo[3,2-d]pyrimidine derivatives: Novel VEGFR2 kinase inhibitors binding to inactive kinase conformation
  作者：Yuya Oguro、Naoki Miyamoto、Kengo Okada、Terufumi Takagi、Hidehisa Iwata、Yoshiko Awazu、Hiroshi Miki、Akira Hori、Keiji Kamiyama、Shinichi Imamura

  DOI：10.1016/j.bmc.2010.08.017

  日期：2010.10.15

  We synthesized a series of pyrrolo[3,2-d] pyrimidine derivatives and evaluated their application as type-II inhibitors of vascular endothelial growth factor receptor 2 (VEGFR2) kinase. Incorporation of a diphenylurea moiety at the C4-position of the pyrrolo[3,2-d] pyrimidine core via an oxygen linker resulted in compounds that were potent inhibitors of VEGFR2 kinase. Of these derivatives, compound 20d showed the strongest inhibition of VEGF-stimulated proliferation of human umbilical vein endothelial cells (HUVEC). The co-crystal structure of 20d and VEGFR2 revealed that 20d binds to the inactive form of VEGFR2. Further studies indicated that 20d inhibited VEGFR2 kinase with slow dissociation kinetics and also inhibited PDGFR and Tie-2 kinases. Oral administration of the hydrochloride salt of 20d at 3 mg/kg/day showed potent inhibition of tumor growth in a DU145 human prostate cancer cell xenograft nude mouse model. (C) 2010 Elsevier Ltd. All rights reserved.