[2-(Naphthalen-2-ylmethylamino)phenyl]-piperazin-1-ylmethanone | 1235987-73-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: [2-(Naphthalen-2-ylmethylamino)phenyl]-piperazin-1-ylmethanone
• CAS: 1235987-73-1
• 化学式: C₂₂H₂₃N₃O
• 分子量: 345.444
• InChiKey: PPZGTZQUGWCRQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  44.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  [2-(Naphthalen-2-ylmethylamino)phenyl]-piperazin-1-ylmethanone 、 (2S)-N-[4-(5-bromopentyloxy)-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 24.0h， 生成 (S)-(2-(bis(ethylthio)methyl)pyrrolidin-1-yl)(5-methoxy-4-((5-(4-(2-((naphthalen-2-ylmethyl)amino)benzoyl)piperazin-1-yl)pentyl)oxy)-2-nitrophenyl)methanone
  参考文献：
  名称：

  Synthesis, anticancer activity and apoptosis inducing ability of anthranilamide-PBD conjugates

  摘要：

  A series of novel anthranilamide linked pyrrolo[2,1-c][1,4] benzodiazepine conjugates were prepared and evaluated for their anticancer activity. The effects of three promising PBD conjugates on cell cycle of cancerous cell line A375 were investigated. These promising compounds showed the characteristic features of apoptosis like enhancement in the levels of p53 and activation of caspase-3. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.04.037
• 作为产物：
  描述：

  tert-butyl 4-(2-((naphthalen-2-ylmethyl)amino)benzoyl)piperazine-1-carboxylate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 生成 [2-(Naphthalen-2-ylmethylamino)phenyl]-piperazin-1-ylmethanone
  参考文献：
  名称：

  Synthesis, anticancer activity and apoptosis inducing ability of anthranilamide-PBD conjugates

  摘要：

  A series of novel anthranilamide linked pyrrolo[2,1-c][1,4] benzodiazepine conjugates were prepared and evaluated for their anticancer activity. The effects of three promising PBD conjugates on cell cycle of cancerous cell line A375 were investigated. These promising compounds showed the characteristic features of apoptosis like enhancement in the levels of p53 and activation of caspase-3. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.04.037

文献信息

• Synthesis, anticancer activity and apoptosis inducing ability of anthranilamide-PBD conjugates
  作者：Ahmed Kamal、E. Vijaya Bharathi、M. Janaki Ramaiah、J. Surendranadha Reddy、D. Dastagiri、A. Viswanath、Farheen Sultana、S.N.C.V.L. Pushpavalli、Manika Pal-Bhadra、Aarti Juvekar、Subrata Sen、Surekha Zingde

  DOI：10.1016/j.bmcl.2010.04.037

  日期：2010.6

  A series of novel anthranilamide linked pyrrolo[2,1-c][1,4] benzodiazepine conjugates were prepared and evaluated for their anticancer activity. The effects of three promising PBD conjugates on cell cycle of cancerous cell line A375 were investigated. These promising compounds showed the characteristic features of apoptosis like enhancement in the levels of p53 and activation of caspase-3. (C) 2010 Elsevier Ltd. All rights reserved.