Lyn peptide inhibitor

• 分子结构分类: 有机化合物 - 有机聚合物 - 多肽
• 英文名称: Lyn peptide inhibitor
• 英文别名: (4S)-5-[[(2S)-6-amino-1-[[(2S,3S)-1-[(2S)-2-[[(2S)-4-amino-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-1,4-dioxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-5-carbamimidamido-2-[[(2S)-5-carbamimidamido-2-[[(2S)-2-[[(2S)-5-carbamimidamido-2-[[(2S)-3-(4-hydroxyphenyl)-2-[[2-[[(2S)-3-(4-hydroxyphenyl)-2-(octadecanoylamino)propanoyl]amino]acetyl]amino]propanoyl]amino]pentanoyl]amino]-4-methylpentanoyl]amino]pentanoyl]amino]pentanoyl]amino]hexanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoic acid
• 化学式: C₁₁₅H₁₈₄N₃₀O₂₄
• 分子量: 2370.9
• InChiKey: MITSVNFZLBORMW-QMGLJYLZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  169
• 可旋转键数：
  87
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  903
• 氢给体数：
  32
• 氢受体数：
  29

文献信息

• [EN] TREATMENTS FOR MELANOMA<br/>[FR] TRAITEMENTS DU MÉLANOME
  申请人：UNIV TEXAS

  公开号：WO2014039741A2

  公开（公告）日：2014-03-13

  The present invention relates to mono- and combination therapies for melanoma, and in particular, metastatic melanoma. Drugs for use in such therapies in include RO 31-8220, bafetinib, and cardiac glycosides.
• [EN] COMBINATION TREATMENTS FOR MELANOMA<br/>[FR] POLYTHÉRAPIES POUR TRAITER LE MÉLANOME
  申请人：UNIV TEXAS

  公开号：WO2014039742A1

  公开（公告）日：2014-03-13

  The present invention relates to combination therapies for melanoma, and in particular, metastatic melanoma. Drugs for use in such therapies in include BRAF inhibitors such as PLX 4720 and PLX 4734 in combination with RO 31-8220, bafetinib or cardiac glycosides.