1-[(2R,3R,4R,5R)-3-benzyl-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 1-[(2R,3R,4R,5R)-3-benzyl-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
• 化学式: C₁₆H₁₈N₂O₆
• 分子量: 334.32
• InChiKey: FDCVJNTUHGNMFA-XKVFNRALSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  119
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
  申请人：Carr Brian Allen

  公开号：US20150299696A1

  公开（公告）日：2015-10-22

  The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity, and/or modulate a gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against target gene expression.

  本发明涉及化合物、组合物和方法，用于研究、诊断和治疗对基因表达和/或活性调节、和/或调节基因表达途径有反应的特征、疾病和病症。具体而言，本发明涉及双链核酸分子，包括小核酸分子，如短干扰核酸（siNA）分子，能够介导或介导靶基因表达的RNA干扰（RNAi）。
• SHORT INTERFERING NUCLEIC ACID (SINA) COMPOSITIONS
  申请人：Sirna Therapeutics, Inc.

  公开号：EP3358013A1

  公开（公告）日：2018-08-08

  The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity, and/or modulate a gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against target gene expression.

  本发明涉及用于研究、诊断和治疗对基因表达和/或活性调节和/或基因表达途径调节有反应的性状、疾病和病症的化合物、组合物和方法。具体来说，本发明涉及双链核酸分子，包括小核酸分子，如短干扰核酸（siNA）分子，它们能够介导或介导针对靶基因表达的 RNA 干扰（RNAi）。
• Short interfering nucleic acid (siNA) compositions
  申请人：SIRNA THERAPEUTICS, INC.

  公开号：US10689648B2

  公开（公告）日：2020-06-23

  The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity, and/or modulate a gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against target gene expression.

  本发明涉及用于研究、诊断和治疗对基因表达和/或活性调节和/或基因表达途径调节有反应的性状、疾病和病症的化合物、组合物和方法。具体来说，本发明涉及双链核酸分子，包括小核酸分子，如短干扰核酸（siNA）分子，它们能够介导或介导针对靶基因表达的 RNA 干扰（RNAi）。
• [EN] SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS<br/>[FR] COMPOSITIONS DE PETIT ACIDE NUCLÉIQUE INTERFÉRENT (SINA)
  申请人：MERCK SHARP & DOHME

  公开号：WO2013165816A2

  公开（公告）日：2013-11-07

  The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity, and/or modulate a gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against target gene expression.