N-[4-(1-benzoylazetidin-3-yl)phenyl]-3-(pyridin-3-yl)azetidine-1-carboxamide | 1485068-32-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂环丁烷
• 英文名称: N-[4-(1-benzoylazetidin-3-yl)phenyl]-3-(pyridin-3-yl)azetidine-1-carboxamide
• 英文别名: N-[4-(1-benzoylazetidin-3-yl)phenyl]-3-pyridin-3-ylazetidine-1-carboxamide
• CAS: 1485068-32-3
• 化学式: C₂₅H₂₄N₄O₂
• 分子量: 412.491
• InChiKey: CPJNJDQZJOBYLI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  65.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• NAMPT INHIBITORS
  申请人：AbbVie Inc.

  公开号：US20140336168A1

  公开（公告）日：2014-11-13

  Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.

  揭示了一种抑制NAMPT活性的化合物，含有这些化合物的组合物以及治疗NAMPT表达疾病的方法。
• [EN] NAMPT INHIBITORS<br/>[FR] INHIBITEURS DE NAMPT
  申请人：ABBVIE INC

  公开号：WO2013170113A1

  公开（公告）日：2013-11-14

  Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.

  揭示了抑制NAMPT活性的化合物，含有这些化合物的组合物以及治疗NAMPT表达疾病的方法。
• SUBSTITUTED PYRIDINE DERIVATIVES AS FABI INHIBITORS
  申请人：Aurigene Discovery Technologies Limited

  公开号：US20140336153A1

  公开（公告）日：2014-11-13

  The present invention provides substituted pyridine derivatives of formula (I), which may be therapeutically useful as as anti-bacterial agents, more particularly FabI inhibitors. Formula (I) in which R1 to R5 and L have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention in diseases or disorder, in particular their use in diseases or disorder where there is an advantage anti-bacterial agents, more particularly FabI inhibitors. The present invention also provides methods for synthesizing and administering the FabI inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the FabI inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor.

  本发明提供了式（I）的取代吡啶衍生物，其可作为抗菌剂，更特别地是FabI抑制剂，具有治疗上的用途。式（I）中，R1至R5和L具有规范中所给出的含义，以及其药学上可接受的盐，在特定的疾病或疾病预防治疗中有用，特别是在有优势的抗菌剂，更特别地是FabI抑制剂的疾病或疾病预防治疗中的使用。本发明还提供了合成和给予FabI抑制剂化合物的方法。本发明还提供了包含至少一种FabI抑制剂化合物的药物配方，以及与其药学上可接受的载体、稀释剂或赋形剂一起使用的药物配方。
• US9062002B2
  申请人：——

  公开号：US9062002B2

  公开（公告）日：2015-06-23
• US9296723B2
  申请人：——

  公开号：US9296723B2

  公开（公告）日：2016-03-29