2-[[8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-2,6-dioxo-8H-purin-9-yl]methyl]quinoline-3-carbonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2-[[8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-2,6-dioxo-8H-purin-9-yl]methyl]quinoline-3-carbonitrile
• 化学式: C₂₆H₂₈N₈O₂
• 分子量: 484.6
• InChiKey: YGBYTXJOADAYBK-ICCFGIFFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  36
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  122
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• USE OF KERATINOCYTES AS A BIOLOGICALLY ACTIVE SUBSTANCE IN THE TREATMENT OF WOUNDS, SUCH AS DIABETIC WOUNDS, OPTIONALLY IN COMBINATION WITH A DPP-4 INHIBITOR
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP2854824A1

  公开（公告）日：2015-04-08
• [EN] USE OF KERATINOCYTES AS A BIOLOGICALLY ACTIVE SUBSTANCE IN THE TREATMENT OF WOUNDS, SUCH AS DIABETIC WOUNDS, OPTIONALLY IN COMBINATION WITH A DPP-4 INHIBITOR<br/>[FR] UTILISATION DE KÉRATINOCYTES EN TANT QUE SUBSTANCE BIOLOGIQUEMENT ACTIVE DANS LE TRAITEMENT DES PLAIES, PAR EXEMPLE DES PLAIES DIABÉTIQUES, FACULTATIVEMENT EN COMBINAISON AVEC UN INHIBITEUR DE LA DPP-4
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2013174769A1

  公开（公告）日：2013-11-28

  The invention relates to new keratinocytes which may be cultured in vitro and the use thereof for preparing a product which can be used to treat acute and chronic wounds, in combination with a DPP-4 inhibitor.