6-deuterio-1-(1-methylcyclopropyl)-3H-imidazo[4,5-c]pyridin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 6-deuterio-1-(1-methylcyclopropyl)-3H-imidazo[4,5-c]pyridin-2-one
• 化学式: C10H11N3O
• 分子量: 190.22
• InChiKey: FRESSSMANSURES-UICOGKGYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  45.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] 1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE DERIVATIVES SUBSTITUTED WITH BENZIMIDAZOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS<br/>[FR] DÉRIVÉS DE 1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE SUBSTITUÉS PAR DES BENZIMIDAZOLES UTILISÉS COMME AGENTS ANTIVIRAUX CONTRE LE VIRUS RESPIRATOIRE SYNCYTIAL
  申请人：JANSSEN R & D IRELAND

  公开号：WO2013186334A1

  公开（公告）日：2013-12-19

  The present invention is concerned with novel 1,3-dihydro-2H-benzimidazol-2-one derivatives substituted with benzimidazoles having formula (I) stereoisomeric forms thereof, and the pharmaceutically acceptable addition salts, and the solvates thereof, wherein R4, R5, Z and Het have the meaning defined in the claims. The compounds according to the present invention are useful as inhibitors on the replication of the respiratory syncytial virus (RSV). The invention further concerns the preparation of such novel compounds, compositions comprising these compounds, and the compounds for use in the treatment of respiratory syncytial virus infection.

  本发明涉及一种新型1,3-二氢-2H-苯并咪唑-2-酮衍生物，其被苯并咪唑取代，具有式（I）的立体异构体形式，以及其药学上可接受的加盐物和溶剂化物，其中R4、R5、Z和Het的含义如权利要求所定义。本发明的化合物可用作呼吸道合胞病毒（RSV）复制的抑制剂。本发明还涉及制备这种新型化合物、包含这些化合物的组合物以及用于治疗呼吸道合胞病毒感染的化合物。
• NOVEL 1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE DERIVATIVES SUBSTITUTED WITH BENZIMIDAZOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS
  申请人：Janssen R&D Ireland

  公开号：US20150166533A1

  公开（公告）日：2015-06-18

  The present invention is concerned with novel 1,3-dihydro-2H-benzimidazol-2-one derivatives substituted with benzimidazoles having formula (I) stereoisomeric forms thereof, and the pharmaceutically acceptable addition salts, and the solvates thereof, wherein R 4 , R 5 , Z and Het have the meaning defined in the claims. The compounds according to the present invention are useful as inhibitors on the replication of the respiratory syncytial virus (RSV). The invention further concerns the preparation of such novel compounds, compositions comprising these compounds, and the compounds for use in the treatment of respiratory syncytial virus infection.

  本发明涉及具有式(I)苯并咪唑取代的新型1,3-二氢-2H-苯并咪唑-2-酮衍生物及其立体异构体形式，以及药学上可接受的加合物盐和溶剂化物，其中R4、R5、Z和Het在权利要求中定义。本发明的化合物可用作呼吸道合胞病毒(RSV)复制的抑制剂。本发明进一步涉及制备这些新型化合物、含有这些化合物的组合物以及用于治疗呼吸道合胞病毒感染的化合物。
• 1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE DERIVATIVES SUBSTITUTED WITH BENZIMIDAZOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS
  申请人：Janssen Sciences Ireland UC

  公开号：EP2864325A1

  公开（公告）日：2015-04-29