4-(4-Chlorobutyl)benzo[e]isoindole-1,3-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 4-(4-Chlorobutyl)benzo[e]isoindole-1,3-dione
• 英文别名: 4-(4-chlorobutyl)benzo[e]isoindole-1,3-dione
• 化学式: C₁₆H₁₄ClNO₂
• 分子量: 287.74
• InChiKey: CQJGSHMOYADSNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] METHODS OF ACUTE RESTORATION OF VASCULAR COMPLIANCE<br/>[FR] MÉTHODES DE RESTAURATION AIGUË D'UNE COMPLIANCE VASCULAIRE
  申请人：ALUMEND LLC

  公开号：WO2014152564A1

  公开（公告）日：2014-09-25

  Disclosed herein is a compound for use in a composition applied to a blood vessel, wherein the compound softens and/or disrupts the crystalline matrix of calcified plaque, as well as acutely restoring the vascular compliance at the treatment site of the blood vessel, while maintaining luminal gain during angioplasty. Methods of treatment comprising applying the disclosed composition are also disclosed. Plaque-softening compounds are also disclosed.

  本文披露了一种化合物，用于制成应用于血管的组合物，其中该化合物软化和/或破坏了钙化斑块的晶体基质，并在治疗部位急性恢复血管顺应性，同时在血管成形术期间保持腔内增益。还披露了应用所披露的组合物的治疗方法。还披露了软化斑块的化合物。
• Methods of acute restoration of vascular compliance
  申请人：Alumend, LLC

  公开号：US10959995B2

  公开（公告）日：2021-03-30

  Disclosed herein is a compound for use in a composition applied to a blood vessel, wherein the compound softens and/or disrupts the crystalline matrix of calcified plaque, as well as acutely restoring the vascular compliance at the treatment site of the blood vessel, while maintaining luminal gain during angioplasty. Methods of treatment comprising applying the disclosed composition are also disclosed. Plaque-softening compounds are also disclosed.

  本文公开了一种用于血管的组合物中的化合物，其中的化合物能软化和/或破坏钙化斑块的结晶基质，并能迅速恢复血管治疗部位的血管顺应性，同时在血管成形术期间保持管腔增大。还公开了包括应用所公开组合物的治疗方法。还公开了斑块软化化合物。
• COMPOSITIONS AND METHODS OF USING THE COMPOSITIONS FOR PLAQUE SOFTENING
  申请人：Alumend, LLC

  公开号：EP2970227A1

  公开（公告）日：2016-01-20
• METHODS OF ACUTE RESTORATION OF VASCULAR COMPLIANCE
  申请人：Alumend, LLC

  公开号：EP2976081A1

  公开（公告）日：2016-01-27
• [EN] COMPOSITIONS AND METHODS OF USING THE COMPOSITIONS FOR PLAQUE SOFTENING<br/>[FR] COMPOSITIONS ET MÉTHODES D'UTILISATION DES COMPOSITIONS POUR RAMOLLIR DES PLAQUES CALCIFIÉES
  申请人：ALUMEND LLC

  公开号：WO2014022807A2

  公开（公告）日：2014-02-06

  Disclosed herein is a compound for use in a composition applied to a blood vessel, wherein the compound softens and/or disrupts the crystalline matrix of calcified plaque. Methods of treatment comprising applying the disclosed composition are also disclosed. Plaque-softening compounds are also disclosed.