3-chloro-6-phenyl-7-(7H-purin-6-yloxymethyl)-5H-imidazo[1,2-c]pyrimidin-5-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 3-chloro-6-phenyl-7-(7H-purin-6-yloxymethyl)-5H-imidazo[1,2-c]pyrimidin-5-ol
• 化学式: C₁₈H₁₄ClN₇O₂
• 分子量: 395.8
• InChiKey: AXEINDYYFCWFHG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] NOVEL HETEROARYL AND HETEROCYCLE COMPOUNDS, COMPOSITIONS AND METHODS<br/>[FR] NOUVEAUX COMPOSÉS HÉTÉROARYLIQUES ET HÉTÉROCYCLIQUES ET COMPOSITIONS ET PROCÉDÉS S'Y RAPPORTANT
  申请人：HUTCHISON MEDIPHARMA LTD

  公开号：WO2014015523A1

  公开（公告）日：2014-01-30

  The invention relates to novel heteroaryl and heterocycle compounds and pharmaceutical compositions comprising them, uses and methods thereof for inhibiting the activity of PI3k and for treating inflammatory and autoimmune disorders diseases and cancer.

  这项发明涉及新颖的杂环芳基和杂环化合物，以及包括它们的药物组合物，用途和方法，用于抑制PI3k的活性，并用于治疗炎症性和自身免疫性疾病以及癌症。
• COMPOSITIONS COMPRISING A BIOLOGICAL CONTROL AGENT AND AN INSECTICIDE
  申请人：Bayer CropScience AG

  公开号：EP2854536A1

  公开（公告）日：2015-04-08
• [EN] COMPOSITIONS COMPRISING A BIOLOGICAL CONTROL AGENT AND AN INSECTICIDE<br/>[FR] COMPOSITIONS COMPRENANT UN AGENT DE LUTTE BIOLOGIQUE ET UN INSECTICIDE
  申请人：BAYER CROPSCIENCE AG

  公开号：WO2013178666A1

  公开（公告）日：2013-12-05

  The present invention relates to a composition comprising at least one biological control agent selected from the group consisting of Bacillus chitinosporus AQ746 (NRRL Accession No. B-21 61 8), Bacillusmycoides AQ726 (NRRL Accession No. B-21664). Bacillus pumilus (NRRL Accession No. B- 30087), Bacillus pumilus AQ71 7 (NRRL Accession No. B-21662), Bacillus sp. AQl 75 (ATCC Accession No. 55608), Bacillus sp. AQl 77 (ATCC Accession No, 55609), Bacillus sp. AQl 78 (ATCC Accession No. 53522), Bacillus subtilis AQ743 (NRRL Accession No. B-21665), Bacillus subtilis AQ71 3 (NRRL Accession No. B- 21661 ), Bacillus subtilis AQl 53 (ATCC Accession No. 55614), Bacillus thuringiensis BD#32 (NRRL Accession No, B-21530), Bacillus thuringiensis AQ52 (NRRL Accession No. B-21 61 9), Muscodor albus 620 (NRRL Accession No. 30547), Muscodor roseus A3-5 (NRRL Accession No. 30548), Rhodococcus globerulus AQ71 9 (NRRL Accession No. B-21663), Streptomyces galbus (NRRL Accession No. 30232), Streptomyces sp. (NRRL Accession No. B-30145), Bacillus thuringiensis subspec. kurstaki BMP 123, Bacillus subtilis AQ30002 (NRRL Accession No, B-50421 ), and Bacillus subtilis AQ 30004 (NRRL Accession No. B-50455) and/or a mutant of these strains having all the identifying characteristics of the respective strain, and/or a metabolite produced by the respective strain that exhibits activity against insects, mites, nematodes and/or phytopathogens and at least one insecticide in a synergistically effective amount, with the proviso that the biological control agent and the insecticide are not identical. Furthermore, the present invention relates to the use of this composition as well as a method for reducing overall damage of plants and plant parts.