(2S,3S,4R)-3,4-dihydroxy-5-[6-[(3-iodophenyl)methylamino]purin-9-yl]oxy-N-methyloxolane-2-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: (2S,3S,4R)-3,4-dihydroxy-5-[6-[(3-iodophenyl)methylamino]purin-9-yl]oxy-N-methyloxolane-2-carboxamide
• 化学式: C₁₈H₁₉IN₆O₅
• 分子量: 526.3
• InChiKey: FETXIVRRAOYFIJ-CDJKEZFESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  144
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• A3 ADENOSINE RECEPTOR LIGANDS FOR USE IN TREATMENT OF A SEXUAL DYSFUNCTION
  申请人：Can-Fite Biopharma Ltd.

  公开号：EP2892533A1

  公开（公告）日：2015-07-15
• [EN] A3 ADENOSINE RECEPTOR LIGANDS FOR USE IN TREATMENT OF A SEXUAL DYSFUNCTION<br/>[FR] LIGANDS DU RÉCEPTEUR A3 DE L'ADÉNOSINE POUR L'UTILISATION DANS LE TRAITEMENT D'UN DYSFONCTIONNEMENT SEXUEL
  申请人：CAN FITE BIOPHARMA LTD

  公开号：WO2014024195A1

  公开（公告）日：2014-02-13

  The present disclosure provides an A3 adenosine receptor (A3AR) ligand for the treatment of sexual dysfunction. In some embodiments the A3AR ligand is selected from an A3AR agonist and A3AR allosteric enhancer. The present disclosure also provides a method a method and pharmaceutical composition for treating a sexual dysfunction, the method comprises administering to a subject having the sexual dysfunction an amount of an A3 adenosine receptor (A3AR) ligand. In some embodiments, the A3AR ligand is an A3AR agonist and more specifically, IB-MECA.