butyl (2R)-2-[[[(2R,3R,4R,5R)-4-chloro-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: butyl (2R)-2-[[[(2R,3R,4R,5R)-4-chloro-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate
• 化学式: C₂₃H₃₁ClN₃O₉P
• 分子量: 559.9
• InChiKey: TVWGOOSIKRBHPH-UNGBFZJXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  37
• 可旋转键数：
  13
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  153
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• D-AMINO ACID COMPOUNDS FOR LIVER DISEASE
  申请人：Idenix Pharmaceuticals LLC

  公开号：US20160002281A1

  公开（公告）日：2016-01-07

  Provided herein are compounds, compositions and methods for the treatment of liver disease and conditions, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.

  本文提供了用于治疗肝脏疾病和病状（包括HCV感染）的化合物、组合物和方法。在某些实施例中，披露了核苷衍生物的化合物和组合物，可以单独或与其他抗病毒药物联合使用。
• [EN] D-AMINO ACID COMPOUNDS FOR LIVER DISEASE<br/>[FR] COMPOSÉS D'ACIDE D-AMINÉ CONTRE LES MALADIES HÉPATIQUES
  申请人：IDENIX PHARMACEUTICALS INC

  公开号：WO2013177219A1

  公开（公告）日：2013-11-28

  Provided herein are compounds comprising a D-amino acid, compositions and methods for the treatment of liver disease and conditions, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.

  本文提供了包含D-氨基酸的化合物、用于治疗肝脏疾病和状况（包括HCV感染）的组合物和方法。在某些实施例中，披露了核苷衍生物的化合物和组合物，可以单独或与其他抗病毒剂联合使用。
• NUCLEOSIDE PHOSPHORAMIDATE PRODRUGS
  申请人：Gilead Pharmasset LLC

  公开号：US20140315852A1

  公开（公告）日：2014-10-23

  Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure: Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.

  本文披露了一种用于治疗哺乳动物病毒感染的核苷衍生物的磷酰胺酰胺前药，该化合物及其立体异构体，盐（酸性或碱性加成盐），水合物，溶剂化物或其结晶形式，由以下结构表示：同时还披露了使用公式I所表示的化合物的治疗方法，用途和制备过程。
• 2'-CHLORO NUCLEOSIDE ANALOGS FOR HCV INFECTION
  申请人：Idenix Pharmaceuticals, Inc.

  公开号：US20160083413A1

  公开（公告）日：2016-03-24

  Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 2′-chloro nucleosides according to Formula 2001: or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form or polymorphic form thereof, wherein B, Z and PD are as described herein.

  本文提供了用于治疗黄病毒科感染，包括丙型肝炎(HCV)感染的化合物、组合物和方法。在某些实施例中，公开了核苷衍生物的化合物和组合物，可以单独或与其他抗病毒药物联合使用。在某些实施例中，化合物是根据公式2001的2'-氯核苷，或其药学上可接受的盐、溶剂化合物、立体异构体形式、互变异构体形式或多态形式，其中B、Z和PD如本文所述。
• D-amino acid compounds for liver disease
  申请人：IDENIX PHARMACEUTICALS LLC

  公开号：US10717758B2

  公开（公告）日：2020-07-21

  Provided herein are compounds, compositions and methods for the treatment of liver disease and conditions, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.

  本文提供了用于治疗肝病和肝脏状况（包括 HCV 感染）的化合物、组合物和方法。在某些实施方案中，公开了核苷衍生物的化合物和组合物，可单独使用或与其他抗病毒药物联合使用。