2-(Oxan-2-yloxy)ethyl 2-ethoxycarbonyloxyacetate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: 2-(Oxan-2-yloxy)ethyl 2-ethoxycarbonyloxyacetate
• 英文别名: 2-(oxan-2-yloxy)ethyl 2-ethoxycarbonyloxyacetate
• 化学式: C₁₂H₂₀O₇
• 分子量: 276.28
• InChiKey: DQBNSARGLLNKEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  19
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  80.3
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• [EN] POLYCARBONATES BEARING PENDANT PRIMARY AMINES FOR MEDICAL APPLICATIONS<br/>[FR] POLYCARBONATES PORTANT DES AMINES PRIMAIRES LATÉRALES POUR DES APPLICATIONS MÉDICALES
  申请人：IBM

  公开号：WO2014042924A1

  公开（公告）日：2014-03-20

  An antimicrobial composition comprises an anionic drug and an amine polymer comprising a first repeat unit of formula (2); wherein a' is an integer equal to 1 or 2, b' is an integer equal to 1 or 2, and each R' is an independent monovalent radical selected from the group consisting of hydrogen, methyl, ethyl, and combinations thereof. G' is a divalent linking group selected from the group consisting of a single bond and groups comprising at least one carbon. X¯ is a negatively charged counterion. The drug and the amine polymer are bound by noncovalent interactions.

  一种抗微生物组合物包括一种阴离子药物和一种胺聚合物，该胺聚合物包括公式（2）的第一重复单元；其中a'是等于1或2的整数，b'是等于1或2的整数，每个R'是从氢、甲基、乙基和它们的组合中选取的独立一价基团。G'是从单键和至少含有一个碳的基团中选取的二价连接基团。X¯是带负电的对离子。药物和胺聚合物通过非共价相互作用结合。
• ANTIMICROBIAL POLYMERS AND METHODS OF MANUFACTURE THEREOF
  申请人：International Business Machines Corporation

  公开号：EP2516503B1

  公开（公告）日：2016-07-20
• BIODEGRADABLE POLYMERS, COMPLEXES THEREOF FOR GENE THERAPEUTICS AND DRUG DELIVERY, AND METHODS RELATED THERETO
  申请人：International Business Machines Corporation

  公开号：EP2516504B1

  公开（公告）日：2015-12-02
• [EN] POLYCARBONATES BEARING AROMATIC N-HETEROCYCLES FOR DRUG DELIVERY<br/>[FR] POLYCARBONATES PORTANT DES N-HÉTÉROCYCLES AROMATIQUES POUR L'ADMINISTRATION D'UN MÉDICAMENT
  申请人：IBM

  公开号：WO2015083377A1

  公开（公告）日：2015-06-11

  Nanoparticles comprise a drug, a first block polymer and a second block polymer. The first block polymer has a poly(ethylene oxide) (PEO) block and a polycarbonate block bearing a side chain aromatic nitrogen-containing heterocycle (N-heterocycle). The N-heterocycle can be in the form of a base, a hydrosalt of the base, a sulfobetaine adduct of the base, or a combination thereof. The second block polymer has a PEO block and a polycarbonate block bearing a side chain catechol group, which can be present as a catechol, oxidized form of a catechol, and/or a polymerized form of a catechol. The nanoparticles can be dispersed in water and are capable of controlled release of the drug.
• [EN] FLUORO-ALCOHOL ADDITIVES FOR ORIENTATION CONTROL OF BLOCK COPOLYMERS<br/>[FR] ADDITIFS FLUORO-ALCOOL POUR COMMANDER L'ORIENTATION DE COPOLYMÈRES SÉQUENCÉS
  申请人：IBM

  公开号：WO2016132247A1

  公开（公告）日：2016-08-25

  A film layer comprising a high-chi (ϰ) block copolymer for self-assembly and a hexafluoroalcohol-containing surface active polymer (SAP) was prepared on a substrate surface that was neutral wetting to the domains of the self-assembled block copolymer. The block copolymer comprises at least one polycarbonate block and at least one other block (e.g., a substituted or unsubstituted styrene-based block). The film layer, whose top surface has contact with an atmosphere, self-assembles to form a lamellar or cylindrical domain pattern having perpendicular orientation with respect to the underlying surface. Other morphologies (e.g., islands and holes of height 1.0Lo) were obtained with films lacking the SAP. The SAP is preferentially miscible with, and lowers the surface energy of, the domain comprising the polycarbonate block.